Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): High frequency of small size apolipoprotein(a) isoforms

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3 Citations (Scopus)

Abstract

Background: Levels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk. Methods: We determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n = 95). Results: Lp(a) levels differed substantially between animals (range: 4-247 nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23 K4 repeats, and the prevalence of a small size apo(a) (≤22 K4) was 43%. Conclusions: Distribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalJournal of Medical Primatology
Volume44
Issue number3
DOIs
StatePublished - Jun 1 2015

Fingerprint

Apoprotein(a)
Lipoprotein(a)
apolipoproteins
Kringles
Macaca mulatta
lipoproteins
Protein Isoforms
Alleles
alleles
Cercopithecidae
risk factors
genetic variation
Genes
animals
genes

Keywords

  • Apo(a) phenotype
  • K4 repeat
  • Non-human primate
  • Old World monkey

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

@article{9210962b27494739bf897fc0289d8f50,
title = "Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): High frequency of small size apolipoprotein(a) isoforms",
abstract = "Background: Levels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk. Methods: We determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n = 95). Results: Lp(a) levels differed substantially between animals (range: 4-247 nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23 K4 repeats, and the prevalence of a small size apo(a) (≤22 K4) was 43{\%}. Conclusions: Distribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.",
keywords = "Apo(a) phenotype, K4 repeat, Non-human primate, Old World monkey",
author = "Enkhmaa Byambaa and Adnan Abbuthalha and Anuurad Erdembileg and Wei Zhang and Tarantal, {Alice F} and Lars Berglund",
year = "2015",
month = "6",
day = "1",
doi = "10.1111/jmp.12160",
language = "English (US)",
volume = "44",
pages = "117--124",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "3",

}

TY - JOUR

T1 - Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a)

T2 - High frequency of small size apolipoprotein(a) isoforms

AU - Byambaa, Enkhmaa

AU - Abbuthalha, Adnan

AU - Erdembileg, Anuurad

AU - Zhang, Wei

AU - Tarantal, Alice F

AU - Berglund, Lars

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Background: Levels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk. Methods: We determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n = 95). Results: Lp(a) levels differed substantially between animals (range: 4-247 nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23 K4 repeats, and the prevalence of a small size apo(a) (≤22 K4) was 43%. Conclusions: Distribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.

AB - Background: Levels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk. Methods: We determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n = 95). Results: Lp(a) levels differed substantially between animals (range: 4-247 nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23 K4 repeats, and the prevalence of a small size apo(a) (≤22 K4) was 43%. Conclusions: Distribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.

KW - Apo(a) phenotype

KW - K4 repeat

KW - Non-human primate

KW - Old World monkey

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