Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): High frequency of small size apolipoprotein(a) isoforms

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Levels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk. Methods: We determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n = 95). Results: Lp(a) levels differed substantially between animals (range: 4-247 nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23 K4 repeats, and the prevalence of a small size apo(a) (≤22 K4) was 43%. Conclusions: Distribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalJournal of Medical Primatology
Volume44
Issue number3
DOIs
StatePublished - Jun 1 2015

Keywords

  • Apo(a) phenotype
  • K4 repeat
  • Non-human primate
  • Old World monkey

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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