Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides

Thomas W. North, Getachew Sequar, Leroy B. Townsend, John C. Drach, Peter A Barry

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Rhesus and human cytomegalovirus (RhCMV and HCMV, respectively) exhibit comparable inhibition by benzimidazole nucleosides, including 2,5,6-trichloro-(1-β-D-ribofuranosyl)benzimidazole (TCRB), and pyrrolo[2,3-d]pyrimidines. The two HCMV protein targets of TCRB, UL89 and UL56, are highly conserved with their RhCMV homologues. These data indicate that infection of rhesus macaques with RhCMV represents a useful model to test novel anti-HCMV drugs.

Original languageEnglish (US)
Pages (from-to)2760-2765
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number7
DOIs
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Pharmacology (medical)

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