RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload

Jason H Rogers, Praveen Tamirisa, Attila Kovacs, Carla Weinheimer, Michael Courtois, Kendall J. Blumer, Daniel P. Kelly, Anthony J. Muslin

Research output: Contribution to journalArticle

161 Scopus citations

Abstract

RGS family members are GTPase-activating proteins (GAPs) for heterotrimeric G proteins. There is evidence that altered RGS gene expression may contribute to the pathogenesis of cardiac hypertrophy and failure. We investigated the ability of RGS4 to modulate cardiac physiology using a transgenic mouse model. Overexpression of RGS4 in postnatal ventricular tissue did not affect cardiac morphology or basal cardiac function, but markedly compromised the ability of the heart to adapt to transverse aortic constriction (TAC). In contrast to wild-type mice, the transgenic animals developed significantly reduced ventricular hypertrophy in response to pressure overload and also did not exhibit induction of the cardiac 'fetal' gene program. TAC of the transgenic mice caused a rapid decompensation in most animals characterized by left ventricular dilatation, depressed systolic function, and increased postoperative mortality when compared with nontransgenic littermates. These results implicate RGS proteins as a crucial component of the signaling pathway involved in both the cardiac response to acute ventricular pressure overload and the cardiac hypertrophic program.

Original languageEnglish (US)
Pages (from-to)567-576
Number of pages10
JournalJournal of Clinical Investigation
Volume104
Issue number5
StatePublished - Sep 1999
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload'. Together they form a unique fingerprint.

  • Cite this

    Rogers, J. H., Tamirisa, P., Kovacs, A., Weinheimer, C., Courtois, M., Blumer, K. J., Kelly, D. P., & Muslin, A. J. (1999). RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. Journal of Clinical Investigation, 104(5), 567-576.