Reye syndrome. An association with type 1 vaccine like poliovirus

Polio type 1 vaccine like virus was isolated from spinal fluid, ileum, and brain tissue of a 7 yr old girl whose clinical course and postmortem findings were typical of Reye syndrome. History revealed previous immunization with seven courses of inactivated polio vaccine and close contact, three weeks before her illness, with a child recently immunized with oral trivalent attenuated poliovirus.