Abstract
Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9-17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1031-1040 |
| Number of pages | 10 |
| Journal | Journal of Child Psychology and Psychiatry and Allied Disciplines |
| Volume | 47 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 2006 |
| Externally published | Yes |
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Keywords
- Decision-making
- Depression
- Reward
ASJC Scopus subject areas
- Psychiatry and Mental health
- Developmental and Educational Psychology
Cite this
Reward-related decision-making in pediatric major depressive disorder : An fMRI study. / Forbes, Erika E.; Christopher May, J.; Siegle, Greg J.; Ladouceur, Cecile D.; Ryan, Neal D.; Carter, Cameron S; Birmaher, Boris; Axelson, David A.; Dahl, Ronald E.
In: Journal of Child Psychology and Psychiatry and Allied Disciplines, Vol. 47, No. 10, 11.2006, p. 1031-1040.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reward-related decision-making in pediatric major depressive disorder
T2 - An fMRI study
AU - Forbes, Erika E.
AU - Christopher May, J.
AU - Siegle, Greg J.
AU - Ladouceur, Cecile D.
AU - Ryan, Neal D.
AU - Carter, Cameron S
AU - Birmaher, Boris
AU - Axelson, David A.
AU - Dahl, Ronald E.
PY - 2006/11
Y1 - 2006/11
N2 - Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9-17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.
AB - Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9-17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing.
KW - Decision-making
KW - Depression
KW - Reward
UR - http://www.scopus.com/inward/record.url?scp=33750410024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750410024&partnerID=8YFLogxK
U2 - 10.1111/j.1469-7610.2006.01673.x
DO - 10.1111/j.1469-7610.2006.01673.x
M3 - Article
C2 - 17073982
AN - SCOPUS:33750410024
VL - 47
SP - 1031
EP - 1040
JO - Journal of Child Psychology and Psychiatry and Allied Disciplines
JF - Journal of Child Psychology and Psychiatry and Allied Disciplines
SN - 0021-9630
IS - 10
ER -