Revisiting the tubulin cofactors and Arl2 in the regulation of soluble αβ-tubulin pools and their effect on microtubule dynamics

Jawdat Al-Bassam, William Bement

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Soluble αβ-tubulin heterodimers are maintained at high concentration inside eukaryotic cells, forming pools that fundamentally drive microtubule dynamics. Five conserved tubulin cofactors and ADP ribosylation factor-like 2 regulate the biogenesis and degradation of αβ-tubulins to maintain concentrated soluble pools. Here I describe a revised model for the function of three tubulin cofactors and Arl2 as a multisubunit GTP-hydrolyzing catalytic chaperone that cycles to promote αβ-tubulin biogenesis and degradation. This model helps explain old and new data indicating these activities enhance microtubule dynamics in vivo via repair or removal of αβ-tubulins from the soluble pools.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalMolecular Biology of the Cell
Volume28
Issue number3
DOIs
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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