Review of vascularized bone marrow transplantation: Current status and future clinical applications

Chad R. Gordon, Chau Y. Tai, Hidetoshi Suzuki, Louise F. Strande, Rajendra Ramsamooj, Martha S. Matthews, Kirby S. Black, Charles W. Hewitt

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

In this review, we examine the applicability of the vascularized bone marrow transplant (VBMT) as an alternative to conventional bone marrow transplantation (BMT). As a new surgical approach, the VBMT is unique by transplantation of the stromal environment that eliminates the need for an engraftment period, provides critical signaling and modulatory functions, and may potentiate tolerance induction. Thus far, VBMT studies have demonstrated an absence of graft-versus-host disease (GVHD) and robust engraftment into nonmanipulated as well as irradiated recipients with evidence of immunological tolerance. Further investigation is needed to determine the applicability of VBMT as an alternative to BMT.

Original languageEnglish (US)
Pages (from-to)348-353
Number of pages6
JournalMicrosurgery
Volume27
Issue number4
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Review of vascularized bone marrow transplantation: Current status and future clinical applications'. Together they form a unique fingerprint.

  • Cite this

    Gordon, C. R., Tai, C. Y., Suzuki, H., Strande, L. F., Ramsamooj, R., Matthews, M. S., Black, K. S., & Hewitt, C. W. (2007). Review of vascularized bone marrow transplantation: Current status and future clinical applications. Microsurgery, 27(4), 348-353. https://doi.org/10.1002/micr.20367