Review of the Pathways Involved in the Osteogenic Differentiation of Adipose-Derived Stem Cells

Derek B. Asserson, Hakan Orbay, David E Sahar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Grafts and prosthetic materials used for the repair of bone defects are often accompanied by comorbidity and rejection. Therefore, there is an immense need for novel approaches to combating the issues surrounding such defects. Because of their accessibility, substantial proportion, and osteogenic differentiation potential, adipose-derived stem cells (ASCs) make for an ideal source of bone tissue in regenerative medicine. However, efficient induction of ASCs toward an osteoblastic lineage in vivo is met with challenges, and many signaling pathways must come together to secure osteoblastogenesis. Among them are bone morphogenic protein, wingless-related integration site protein, Notch, Hedgehog, fibroblast growth factor, vascular endothelial growth factor, and extracellular regulated-signal kinase. The goal of this literature review is to conglomerate the present research on these pathways to formulate a better understanding of how ASCs are most effectively transformed into bone in the context of tissue engineering.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalThe Journal of craniofacial surgery
Volume30
Issue number3
DOIs
StatePublished - May 1 2019

Fingerprint

Stem Cells
Bone and Bones
Hedgehog Proteins
Notch Receptors
Regenerative Medicine
Fibroblast Growth Factors
Extracellular Signal-Regulated MAP Kinases
Tissue Engineering
Vascular Endothelial Growth Factor A
Comorbidity
Transplants
Research
Proteins

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Review of the Pathways Involved in the Osteogenic Differentiation of Adipose-Derived Stem Cells. / Asserson, Derek B.; Orbay, Hakan; Sahar, David E.

In: The Journal of craniofacial surgery, Vol. 30, No. 3, 01.05.2019, p. 703-708.

Research output: Contribution to journalArticle

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