Reversible magnetic resonance imaging abnormalities in dogs following seizures

Linda M. Mellema, Philip D. Koblik, Gregg D. Kortz, Richard A Lecouteur, Melissa A. Chechowitz, Peter J Dickinson

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Reversible magnetic resonance (MR) imaging lesions have been described in humans following seizures. This condition has not yet been reported in animals. This paper describes reversible abnormalities identified in 3 dogs using MR imaging that was performed initially within 14 days of the last seizure and follow-up imaging that was performed after 10 to 16 weeks of anticonvulsant therapy. All three dogs had lesions in the piriform/temporal lobes, characterized by varying degrees of hyperintensity on T2-weighted images and hypointensity on T1-weighted images. In one dog, contrast enhancement was evident. On reevaluation, partial resolution occurred in all 3 dogs. In a fourth animal with an olfactory meningioma, similar appearing lesions in the temporal cortex and right and left piriform lobes were identified after seizure activity. A surgical biopsy of the temporal cortex and hippocampus was performed and edema, neovascularization, reactive astrocytosis, and acute neuronal necrosis were evident. These histologic findings are similar to those reported in humans with seizures. Recognizing the potential occurrence of reversible abnormalities in MR images is important in developing a diagnostic and therapeutic plan in canine patients with seizures. Repeat imaging after seizure control may help differentiate between seizure-induced changes and primary multifocal parenchymal abnormalities.

Original languageEnglish (US)
Pages (from-to)588-595
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume40
Issue number6
StatePublished - Nov 1999

Fingerprint

seizures
magnetic resonance imaging
Seizures
Magnetic Resonance Imaging
Dogs
dogs
Temporal Lobe
lesions (animal)
cortex
image analysis
anticonvulsants
therapeutics
Gliosis
Meningioma
hippocampus
Operative Time
angiogenesis
Anticonvulsants
edema
Canidae

Keywords

  • Canine
  • Magnetic resonance imaging
  • Reversible
  • Seizures

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Reversible magnetic resonance imaging abnormalities in dogs following seizures. / Mellema, Linda M.; Koblik, Philip D.; Kortz, Gregg D.; Lecouteur, Richard A; Chechowitz, Melissa A.; Dickinson, Peter J.

In: Veterinary Radiology and Ultrasound, Vol. 40, No. 6, 11.1999, p. 588-595.

Research output: Contribution to journalArticle

Mellema, Linda M. ; Koblik, Philip D. ; Kortz, Gregg D. ; Lecouteur, Richard A ; Chechowitz, Melissa A. ; Dickinson, Peter J. / Reversible magnetic resonance imaging abnormalities in dogs following seizures. In: Veterinary Radiology and Ultrasound. 1999 ; Vol. 40, No. 6. pp. 588-595.
@article{96b7b9ca2f7d438685e853b27d4d9d17,
title = "Reversible magnetic resonance imaging abnormalities in dogs following seizures",
abstract = "Reversible magnetic resonance (MR) imaging lesions have been described in humans following seizures. This condition has not yet been reported in animals. This paper describes reversible abnormalities identified in 3 dogs using MR imaging that was performed initially within 14 days of the last seizure and follow-up imaging that was performed after 10 to 16 weeks of anticonvulsant therapy. All three dogs had lesions in the piriform/temporal lobes, characterized by varying degrees of hyperintensity on T2-weighted images and hypointensity on T1-weighted images. In one dog, contrast enhancement was evident. On reevaluation, partial resolution occurred in all 3 dogs. In a fourth animal with an olfactory meningioma, similar appearing lesions in the temporal cortex and right and left piriform lobes were identified after seizure activity. A surgical biopsy of the temporal cortex and hippocampus was performed and edema, neovascularization, reactive astrocytosis, and acute neuronal necrosis were evident. These histologic findings are similar to those reported in humans with seizures. Recognizing the potential occurrence of reversible abnormalities in MR images is important in developing a diagnostic and therapeutic plan in canine patients with seizures. Repeat imaging after seizure control may help differentiate between seizure-induced changes and primary multifocal parenchymal abnormalities.",
keywords = "Canine, Magnetic resonance imaging, Reversible, Seizures",
author = "Mellema, {Linda M.} and Koblik, {Philip D.} and Kortz, {Gregg D.} and Lecouteur, {Richard A} and Chechowitz, {Melissa A.} and Dickinson, {Peter J}",
year = "1999",
month = "11",
language = "English (US)",
volume = "40",
pages = "588--595",
journal = "Veterinary Radiology and Ultrasound",
issn = "1058-8183",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Reversible magnetic resonance imaging abnormalities in dogs following seizures

AU - Mellema, Linda M.

AU - Koblik, Philip D.

AU - Kortz, Gregg D.

AU - Lecouteur, Richard A

AU - Chechowitz, Melissa A.

AU - Dickinson, Peter J

PY - 1999/11

Y1 - 1999/11

N2 - Reversible magnetic resonance (MR) imaging lesions have been described in humans following seizures. This condition has not yet been reported in animals. This paper describes reversible abnormalities identified in 3 dogs using MR imaging that was performed initially within 14 days of the last seizure and follow-up imaging that was performed after 10 to 16 weeks of anticonvulsant therapy. All three dogs had lesions in the piriform/temporal lobes, characterized by varying degrees of hyperintensity on T2-weighted images and hypointensity on T1-weighted images. In one dog, contrast enhancement was evident. On reevaluation, partial resolution occurred in all 3 dogs. In a fourth animal with an olfactory meningioma, similar appearing lesions in the temporal cortex and right and left piriform lobes were identified after seizure activity. A surgical biopsy of the temporal cortex and hippocampus was performed and edema, neovascularization, reactive astrocytosis, and acute neuronal necrosis were evident. These histologic findings are similar to those reported in humans with seizures. Recognizing the potential occurrence of reversible abnormalities in MR images is important in developing a diagnostic and therapeutic plan in canine patients with seizures. Repeat imaging after seizure control may help differentiate between seizure-induced changes and primary multifocal parenchymal abnormalities.

AB - Reversible magnetic resonance (MR) imaging lesions have been described in humans following seizures. This condition has not yet been reported in animals. This paper describes reversible abnormalities identified in 3 dogs using MR imaging that was performed initially within 14 days of the last seizure and follow-up imaging that was performed after 10 to 16 weeks of anticonvulsant therapy. All three dogs had lesions in the piriform/temporal lobes, characterized by varying degrees of hyperintensity on T2-weighted images and hypointensity on T1-weighted images. In one dog, contrast enhancement was evident. On reevaluation, partial resolution occurred in all 3 dogs. In a fourth animal with an olfactory meningioma, similar appearing lesions in the temporal cortex and right and left piriform lobes were identified after seizure activity. A surgical biopsy of the temporal cortex and hippocampus was performed and edema, neovascularization, reactive astrocytosis, and acute neuronal necrosis were evident. These histologic findings are similar to those reported in humans with seizures. Recognizing the potential occurrence of reversible abnormalities in MR images is important in developing a diagnostic and therapeutic plan in canine patients with seizures. Repeat imaging after seizure control may help differentiate between seizure-induced changes and primary multifocal parenchymal abnormalities.

KW - Canine

KW - Magnetic resonance imaging

KW - Reversible

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=0033219160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033219160&partnerID=8YFLogxK

M3 - Article

C2 - 10608685

AN - SCOPUS:0033219160

VL - 40

SP - 588

EP - 595

JO - Veterinary Radiology and Ultrasound

JF - Veterinary Radiology and Ultrasound

SN - 1058-8183

IS - 6

ER -