Reversible immunocontraception in male monkeys immunized with Eppin

M. G. O'Rand, E. E. Widgren, P. Sivashanmugam, R. T. Richardson, S. H. Hall, F. S. French, C. A. VandeVoort, S. G. Ramachandra, V. Ramesh, A. Jagannadha Rao

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males (78%) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.

Original languageEnglish (US)
Pages (from-to)1189-1190
Number of pages2
JournalScience
Volume306
Issue number5699
DOIs
StatePublished - Nov 12 2004

Fingerprint

Immunologic Contraception
Haplorhini
Contraception
Macaca radiata
Male Contraceptive Agents
Epididymis
Family Planning Services
Primates
Fertility
Testis
Immunization
Proteins

ASJC Scopus subject areas

  • General

Cite this

O'Rand, M. G., Widgren, E. E., Sivashanmugam, P., Richardson, R. T., Hall, S. H., French, F. S., ... Jagannadha Rao, A. (2004). Reversible immunocontraception in male monkeys immunized with Eppin. Science, 306(5699), 1189-1190. https://doi.org/10.1126/science.1099743

Reversible immunocontraception in male monkeys immunized with Eppin. / O'Rand, M. G.; Widgren, E. E.; Sivashanmugam, P.; Richardson, R. T.; Hall, S. H.; French, F. S.; VandeVoort, C. A.; Ramachandra, S. G.; Ramesh, V.; Jagannadha Rao, A.

In: Science, Vol. 306, No. 5699, 12.11.2004, p. 1189-1190.

Research output: Contribution to journalArticle

O'Rand, MG, Widgren, EE, Sivashanmugam, P, Richardson, RT, Hall, SH, French, FS, VandeVoort, CA, Ramachandra, SG, Ramesh, V & Jagannadha Rao, A 2004, 'Reversible immunocontraception in male monkeys immunized with Eppin', Science, vol. 306, no. 5699, pp. 1189-1190. https://doi.org/10.1126/science.1099743
O'Rand MG, Widgren EE, Sivashanmugam P, Richardson RT, Hall SH, French FS et al. Reversible immunocontraception in male monkeys immunized with Eppin. Science. 2004 Nov 12;306(5699):1189-1190. https://doi.org/10.1126/science.1099743
O'Rand, M. G. ; Widgren, E. E. ; Sivashanmugam, P. ; Richardson, R. T. ; Hall, S. H. ; French, F. S. ; VandeVoort, C. A. ; Ramachandra, S. G. ; Ramesh, V. ; Jagannadha Rao, A. / Reversible immunocontraception in male monkeys immunized with Eppin. In: Science. 2004 ; Vol. 306, No. 5699. pp. 1189-1190.
@article{8dd4fa43c3a447b0b1285e7c939dbb1f,
title = "Reversible immunocontraception in male monkeys immunized with Eppin",
abstract = "Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males (78{\%}) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71{\%}) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.",
author = "O'Rand, {M. G.} and Widgren, {E. E.} and P. Sivashanmugam and Richardson, {R. T.} and Hall, {S. H.} and French, {F. S.} and VandeVoort, {C. A.} and Ramachandra, {S. G.} and V. Ramesh and {Jagannadha Rao}, A.",
year = "2004",
month = "11",
day = "12",
doi = "10.1126/science.1099743",
language = "English (US)",
volume = "306",
pages = "1189--1190",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5699",

}

TY - JOUR

T1 - Reversible immunocontraception in male monkeys immunized with Eppin

AU - O'Rand, M. G.

AU - Widgren, E. E.

AU - Sivashanmugam, P.

AU - Richardson, R. T.

AU - Hall, S. H.

AU - French, F. S.

AU - VandeVoort, C. A.

AU - Ramachandra, S. G.

AU - Ramesh, V.

AU - Jagannadha Rao, A.

PY - 2004/11/12

Y1 - 2004/11/12

N2 - Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males (78%) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.

AB - Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males (78%) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.

UR - http://www.scopus.com/inward/record.url?scp=8444252111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8444252111&partnerID=8YFLogxK

U2 - 10.1126/science.1099743

DO - 10.1126/science.1099743

M3 - Article

C2 - 15539605

AN - SCOPUS:8444252111

VL - 306

SP - 1189

EP - 1190

JO - Science

JF - Science

SN - 0036-8075

IS - 5699

ER -