Reversible immunocontraception in male monkeys immunized with Eppin

M. G. O'Rand, E. E. Widgren, P. Sivashanmugam, R. T. Richardson, S. H. Hall, F. S. French, C. A. VandeVoort, S. G. Ramachandra, V. Ramesh, A. Jagannadha Rao

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140 Scopus citations

Abstract

Various forms of birth control have been developed for women; however, there are currently few options for men. The development of male contraceptives that are effective, safe, and reversible is desired for family planning throughout the world. We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. Seven out of nine males (78%) developed high titers to Eppin, and all of these high-titer monkeys were infertile. Five out of seven (71%) high-anti-Eppin titer males recovered fertility when immunization was stopped. This study demonstrates that effective and reversible male immunocontraception is an attainable goal. This method of immunocontraception may be extended to humans.

Original languageEnglish (US)
Pages (from-to)1189-1190
Number of pages2
JournalScience
Volume306
Issue number5699
DOIs
StatePublished - Nov 12 2004

ASJC Scopus subject areas

  • General

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