Reversible dermal atrophy in a cat treated with phenytoin

Stephen W Barthold, B. J. Kaplan, A. Schwartz

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks. Dermal collagen was depleted, but remaining collagen seemed structurally normal. Upon cessation of phenytoin treatment, the cat recovered. In an effort to establish an association between phenytoin treatment and a dermal collagen disorder, phenytoin treatment was reported and the dermal lesion confirmed.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalVeterinary Pathology
Volume17
Issue number4
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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