Reversible cross-linked polymeric nanoplatform in drug delivery

Yuanpei Li, Kai Xiao, Kit Lam

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In the past decade, polymeric micelles self-assembled from amphiphilic block copolymers have emerged as a major class of nanocarriers for drug delivery. There has been an increasing interest in using the cross-linking approach to improve the stability of conventional thermodynamic polymeric micelles. Recently, much effort has been directed to the development of reversibly cross-linked micelles that respond to endogenous and/or exogenous stimuli, in particular, pH, temperature or redox potential. Reversibly cross-linked micelles represent an ideal nanocarrier system for targeted drug delivery. These micelles exhibit superior structural stability compared to non-cross-linked counterparts. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive pendants to the block copolymers or the utilization of environmentally sensitive crosslinkers makes these micelles responsive to the endogenous or exogenous stimuli. The release of encapsulated drugs can be readily modulated by these stimuli. The stimuli-responsive release may result in signifi cantly enhanced therapeutic effi cacy and minimized possible side effects. This chapter focuses on the various strategies used for the design, preparation, stimuli-responsiveness and potential medical applications of reversibly cross-linked micelles for drug delivery. In vivo evidence demonstrating the effectiveness of reversibly cross-linked micelles will be presented. Lastly, future perspectives for the development of reversibly cross-linked micelle systems for drug delivery will also be explored.

Original languageEnglish (US)
Title of host publicationNanotechnology and Drug Delivery
Subtitle of host publicationVolume 1: Nanoplatforms in Drug Delivery
PublisherCRC Press
Pages142-177
Number of pages36
ISBN (Electronic)9781466599482
ISBN (Print)9781466599475
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Medicine(all)
  • Engineering(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Li, Y., Xiao, K., & Lam, K. (2014). Reversible cross-linked polymeric nanoplatform in drug delivery. In Nanotechnology and Drug Delivery: Volume 1: Nanoplatforms in Drug Delivery (pp. 142-177). CRC Press. https://doi.org/10.1201/b17271