Abstract
In the past decade, polymeric micelles self-assembled from amphiphilic block copolymers have emerged as a major class of nanocarriers for drug delivery. There has been an increasing interest in using the cross-linking approach to improve the stability of conventional thermodynamic polymeric micelles. Recently, much effort has been directed to the development of reversibly cross-linked micelles that respond to endogenous and/or exogenous stimuli, in particular, pH, temperature or redox potential. Reversibly cross-linked micelles represent an ideal nanocarrier system for targeted drug delivery. These micelles exhibit superior structural stability compared to non-cross-linked counterparts. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive pendants to the block copolymers or the utilization of environmentally sensitive crosslinkers makes these micelles responsive to the endogenous or exogenous stimuli. The release of encapsulated drugs can be readily modulated by these stimuli. The stimuli-responsive release may result in signifi cantly enhanced therapeutic effi cacy and minimized possible side effects. This chapter focuses on the various strategies used for the design, preparation, stimuli-responsiveness and potential medical applications of reversibly cross-linked micelles for drug delivery. In vivo evidence demonstrating the effectiveness of reversibly cross-linked micelles will be presented. Lastly, future perspectives for the development of reversibly cross-linked micelle systems for drug delivery will also be explored.
| Original language | English (US) |
|---|---|
| Title of host publication | Nanotechnology and Drug Delivery |
| Subtitle of host publication | Volume 1: Nanoplatforms in Drug Delivery |
| Publisher | CRC Press |
| Pages | 142-177 |
| Number of pages | 36 |
| ISBN (Electronic) | 9781466599482 |
| ISBN (Print) | 9781466599475 |
| DOIs | |
| State | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Medicine(all)
- Engineering(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Reversible cross-linked polymeric nanoplatform in drug delivery. / Li, Yuanpei; Xiao, Kai; Lam, Kit.
Nanotechnology and Drug Delivery: Volume 1: Nanoplatforms in Drug Delivery. CRC Press, 2014. p. 142-177.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Reversible cross-linked polymeric nanoplatform in drug delivery
AU - Li, Yuanpei
AU - Xiao, Kai
AU - Lam, Kit
PY - 2014/1/1
Y1 - 2014/1/1
N2 - In the past decade, polymeric micelles self-assembled from amphiphilic block copolymers have emerged as a major class of nanocarriers for drug delivery. There has been an increasing interest in using the cross-linking approach to improve the stability of conventional thermodynamic polymeric micelles. Recently, much effort has been directed to the development of reversibly cross-linked micelles that respond to endogenous and/or exogenous stimuli, in particular, pH, temperature or redox potential. Reversibly cross-linked micelles represent an ideal nanocarrier system for targeted drug delivery. These micelles exhibit superior structural stability compared to non-cross-linked counterparts. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive pendants to the block copolymers or the utilization of environmentally sensitive crosslinkers makes these micelles responsive to the endogenous or exogenous stimuli. The release of encapsulated drugs can be readily modulated by these stimuli. The stimuli-responsive release may result in signifi cantly enhanced therapeutic effi cacy and minimized possible side effects. This chapter focuses on the various strategies used for the design, preparation, stimuli-responsiveness and potential medical applications of reversibly cross-linked micelles for drug delivery. In vivo evidence demonstrating the effectiveness of reversibly cross-linked micelles will be presented. Lastly, future perspectives for the development of reversibly cross-linked micelle systems for drug delivery will also be explored.
AB - In the past decade, polymeric micelles self-assembled from amphiphilic block copolymers have emerged as a major class of nanocarriers for drug delivery. There has been an increasing interest in using the cross-linking approach to improve the stability of conventional thermodynamic polymeric micelles. Recently, much effort has been directed to the development of reversibly cross-linked micelles that respond to endogenous and/or exogenous stimuli, in particular, pH, temperature or redox potential. Reversibly cross-linked micelles represent an ideal nanocarrier system for targeted drug delivery. These micelles exhibit superior structural stability compared to non-cross-linked counterparts. Therefore, these nanocarriers are able to minimize the premature drug release during blood circulation. The introduction of environmentally sensitive pendants to the block copolymers or the utilization of environmentally sensitive crosslinkers makes these micelles responsive to the endogenous or exogenous stimuli. The release of encapsulated drugs can be readily modulated by these stimuli. The stimuli-responsive release may result in signifi cantly enhanced therapeutic effi cacy and minimized possible side effects. This chapter focuses on the various strategies used for the design, preparation, stimuli-responsiveness and potential medical applications of reversibly cross-linked micelles for drug delivery. In vivo evidence demonstrating the effectiveness of reversibly cross-linked micelles will be presented. Lastly, future perspectives for the development of reversibly cross-linked micelle systems for drug delivery will also be explored.
UR - http://www.scopus.com/inward/record.url?scp=85054466736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054466736&partnerID=8YFLogxK
U2 - 10.1201/b17271
DO - 10.1201/b17271
M3 - Chapter
AN - SCOPUS:85054466736
SN - 9781466599475
SP - 142
EP - 177
BT - Nanotechnology and Drug Delivery
PB - CRC Press
ER -