Reversible cross-linked polymeric micelles for drug delivery

Lu Zhang, Hao Wu, Yuanpei Li, Kit S. Lam

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biocompatible polymeric nanocarriers can improve the solubility of many toxic anticancer drugs, prolong the in vivo drug circulation time, and allow preferential accumulation of the drugs at the tumor sites via the enhanced permeability and retention effect. To maximize the stability of the nanocarrier and minimize premature drug release during circulation, intraparticle or intramicellar cross-links can be introduced. In this chapter, we will summarize the development of reversibly cross-linked polymeric nanocarriers for on-demand drug release in response to single or multiple stimuli at the tumor microenvironment.

Original languageEnglish (US)
Title of host publicationNanoengineered Biomaterials for Advanced Drug Delivery
PublisherElsevier
Pages243-260
Number of pages18
ISBN (Electronic)9780081029855
DOIs
StatePublished - Jan 1 2020

Keywords

  • Cancer therapy
  • Chemotherapy
  • Cross-links
  • Drug delivery
  • Nanocarrier
  • Nanodelivery
  • Nanomedicine
  • Nanotheranostics
  • Nanotherapeutics
  • Reversible cross-links

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

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