Reversible and irreversible airway inflammation and fibrosis in mice exposed to inhaled ovalbumin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective and design: We examined the reversibility of several changes in the lungs and airways of mice immediately after exposure to ovalbumin aerosol and after a period of recovery breathing clean air. Methods: Mice were exposed for 1, 2, 4, 6, 8, or 10 weeks, with recovery in clean air for 1-3 weeks. Results: Airway collagen content, exhaled NO, airway mucous cell hyperplasia, and lung lavage inflammatory cell content increased upon exposure to ovalbumin aerosol. All parameters except airway fibrosis decreased partially or completely to control values with recovery in clean air. Conclusions: Airway mucous cell hypertrophy and hyperplasia appear to be completely reversible after recovery in clean air, while exhaled NO and airway inflammation appear to be mostly reversible, except for persistence of lymphocytes in the lung lavage fluid. Airway fibrosis appears to be reversible when mice are exposed to ovalbumin aerosol for periods of up to 4 weeks of exposure, but becomes irreversible after 6 or more weeks of exposure.

Original languageEnglish (US)
Pages (from-to)57-65
Number of pages9
JournalInflammation Research
Volume54
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Ovalbumin
Fibrosis
Aerosols
Air
Inflammation
Hyperplasia
Recovery
Bronchoalveolar Lavage Fluid
Bronchoalveolar Lavage
Hypertrophy
Respiration
Collagen
Lymphocytes
Lung
Fluids

Keywords

  • Asthma
  • Eosinophils
  • Lung lavage
  • Mucous cell hyperplasia
  • Nitric oxide

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

@article{fd11af1e8fbe4efb9667e1f6229e46d0,
title = "Reversible and irreversible airway inflammation and fibrosis in mice exposed to inhaled ovalbumin",
abstract = "Objective and design: We examined the reversibility of several changes in the lungs and airways of mice immediately after exposure to ovalbumin aerosol and after a period of recovery breathing clean air. Methods: Mice were exposed for 1, 2, 4, 6, 8, or 10 weeks, with recovery in clean air for 1-3 weeks. Results: Airway collagen content, exhaled NO, airway mucous cell hyperplasia, and lung lavage inflammatory cell content increased upon exposure to ovalbumin aerosol. All parameters except airway fibrosis decreased partially or completely to control values with recovery in clean air. Conclusions: Airway mucous cell hypertrophy and hyperplasia appear to be completely reversible after recovery in clean air, while exhaled NO and airway inflammation appear to be mostly reversible, except for persistence of lymphocytes in the lung lavage fluid. Airway fibrosis appears to be reversible when mice are exposed to ovalbumin aerosol for periods of up to 4 weeks of exposure, but becomes irreversible after 6 or more weeks of exposure.",
keywords = "Asthma, Eosinophils, Lung lavage, Mucous cell hyperplasia, Nitric oxide",
author = "Nicholas Kenyon and Last, {Jerold A}",
year = "2005",
month = "2",
doi = "10.1007/s00011-004-1325-6",
language = "English (US)",
volume = "54",
pages = "57--65",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "2",

}

TY - JOUR

T1 - Reversible and irreversible airway inflammation and fibrosis in mice exposed to inhaled ovalbumin

AU - Kenyon, Nicholas

AU - Last, Jerold A

PY - 2005/2

Y1 - 2005/2

N2 - Objective and design: We examined the reversibility of several changes in the lungs and airways of mice immediately after exposure to ovalbumin aerosol and after a period of recovery breathing clean air. Methods: Mice were exposed for 1, 2, 4, 6, 8, or 10 weeks, with recovery in clean air for 1-3 weeks. Results: Airway collagen content, exhaled NO, airway mucous cell hyperplasia, and lung lavage inflammatory cell content increased upon exposure to ovalbumin aerosol. All parameters except airway fibrosis decreased partially or completely to control values with recovery in clean air. Conclusions: Airway mucous cell hypertrophy and hyperplasia appear to be completely reversible after recovery in clean air, while exhaled NO and airway inflammation appear to be mostly reversible, except for persistence of lymphocytes in the lung lavage fluid. Airway fibrosis appears to be reversible when mice are exposed to ovalbumin aerosol for periods of up to 4 weeks of exposure, but becomes irreversible after 6 or more weeks of exposure.

AB - Objective and design: We examined the reversibility of several changes in the lungs and airways of mice immediately after exposure to ovalbumin aerosol and after a period of recovery breathing clean air. Methods: Mice were exposed for 1, 2, 4, 6, 8, or 10 weeks, with recovery in clean air for 1-3 weeks. Results: Airway collagen content, exhaled NO, airway mucous cell hyperplasia, and lung lavage inflammatory cell content increased upon exposure to ovalbumin aerosol. All parameters except airway fibrosis decreased partially or completely to control values with recovery in clean air. Conclusions: Airway mucous cell hypertrophy and hyperplasia appear to be completely reversible after recovery in clean air, while exhaled NO and airway inflammation appear to be mostly reversible, except for persistence of lymphocytes in the lung lavage fluid. Airway fibrosis appears to be reversible when mice are exposed to ovalbumin aerosol for periods of up to 4 weeks of exposure, but becomes irreversible after 6 or more weeks of exposure.

KW - Asthma

KW - Eosinophils

KW - Lung lavage

KW - Mucous cell hyperplasia

KW - Nitric oxide

UR - http://www.scopus.com/inward/record.url?scp=16244372378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16244372378&partnerID=8YFLogxK

U2 - 10.1007/s00011-004-1325-6

DO - 10.1007/s00011-004-1325-6

M3 - Article

C2 - 15750712

AN - SCOPUS:16244372378

VL - 54

SP - 57

EP - 65

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - 2

ER -