Reverse interactomics: From peptides to proteins and to functions

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Identifying associated partners is critical to understanding the potential function and upstream and downstream pathways of the molecule being studied. The Src homology 2 (SH2) domain is a binding module for peptides containing a phosphotyrosine residue, which is a post-translational modification that is heavily involved in signal transduction. A paper in this issue shows how "reverse interactomics" can be exploited to identify binding partners of the SH2 domain of tensin.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalACS Chemical Biology
Issue number2
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine


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