Identifying associated partners is critical to understanding the potential function and upstream and downstream pathways of the molecule being studied. The Src homology 2 (SH2) domain is a binding module for peptides containing a phosphotyrosine residue, which is a post-translational modification that is heavily involved in signal transduction. A paper in this issue shows how "reverse interactomics" can be exploited to identify binding partners of the SH2 domain of tensin.
ASJC Scopus subject areas
- Molecular Medicine