Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes

W. J. Storkus, J. Alexander, John A Payne, J. R. Dawson, P. Cresswell

Research output: Contribution to journalArticle

228 Scopus citations

Abstract

A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this protection did not extend to cytotoxicity mediated by interleukin 2-stimulated human NK effector cells.

Original languageEnglish (US)
Pages (from-to)2361-2364
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number7
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • General
  • Genetics

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