Retrospective study of desoxycorticosterone pivalate (DOCP) in hypoadrenocorticism dog

Ye rin Coh, Kyoung Won Seo, Jin ok Ahn, Ji sang Chae, Jong woo Park, Dong Ha Bhang, Jun seok Chae, Hwa young Youn, Cheol yong Hwang

Research output: Contribution to journalArticle

Abstract

Hypoadrenocorticism results from the deficient adrenal gland production of glucocorticoids or mineralocorticoids. Fludrocortisone have been used for the management of hypoadrenocorticism in dogs. But desoxycorticosterone pivalate (DOCP) have been administered for management of hypoadrenocorticism in dogs since several years because of the equivalent effect of fludrocortisone, and lessening of owner and patient's effort. The therapy of DOCP was evaluated in 14 dogs diagnosed with hypoadrenocorticism based on clinical signs, an electrolyte imbalance, and the results of an adrenocorticotropic hormone stimulation test. DOCP was administered at 25-day intervals at an initial dose of 2.2 mg/kg. The dogs were monitored for clinical signs and serum electrolyte, blood urea nitrogen, and creatinine concentrations every 25 days. Fludrocortisone was an effective treatment in dogs overall; however, a change to DOCP was necessary in 7 dogs because of adverse effects or poor responses. Another 7 dogs were treated with DOCP from the first time. A total of 14 dogs were treated with DOCP. Clinical signs and electrolyte imbalance resolved completely in 12 dogs. However, mild clinical signs, such as shivering, remained in 2 dogs, and 4 dogs required regular supplementation with prednisone. Improvements in clinical signs and electrolyte imbalance were significantly better after treatment with DOCP than with fludrocortisone. The results suggest that DOCP may be a better choice than fludrocortisone for the management of hypoadrenocorticism in dogs.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalJournal of Veterinary Clinics
Volume28
Issue number2
StatePublished - Aug 15 2011
Externally publishedYes

Keywords

  • DOCP
  • Dogs
  • Fludrocortisone
  • Hypoadrenocorticism

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Coh, Y. R., Seo, K. W., Ahn, J. O., Chae, J. S., Park, J. W., Bhang, D. H., Chae, J. S., Youn, H. Y., & Hwang, C. Y. (2011). Retrospective study of desoxycorticosterone pivalate (DOCP) in hypoadrenocorticism dog. Journal of Veterinary Clinics, 28(2), 244-248.