Retrospective evaluation of toceranib phosphate (Palladia) for treatment of different tumor types in 31 dogs

Seo In Choi, Ye Lim Nam, Jin Kyoung Kim, Hyung Jin Park, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this retrospective study was to provide additional data on the use of toceranib in a wide variety of tumor types in small breed dogs, especially < 8 kg (except 5 dogs). This was a retrospective study of 31 dogs with malignant tumors treated with a 2.5 mg/kg median dose of toceranib (Palladia; Zoetis, USA) on a Monday-Wednesday-Friday schedule. Clinical benefit was observed in 13 of 15 dogs (86.7%, 3 with complete response, 4 with partial response, 6 with stable disease) with gross disease. Distant metastasis, response to treatment, and treatment setting were significantly associated with survival time. Negative prognostic factors were multiple chemotherapy and distant metastasis (affecting progression-free survival [PFS]), surgery, regional enlarged lymph nodes, underlying disease, and toxicity (affecting median survival time [MST]). Positive prognostic factors were epithelial and round cell tumor (affecting PFS), epithelial tumor, microscopic disease, no evidence of disease response, and stable disease (MST). In conclusion, a clinical benefit from toceranib treatment was noted in most of the dogs with gross disease in our study. This study suggested that the toceranib is probably selective treatment to various tumor types in small breed dogs.

Original languageEnglish (US)
Article numbere10
JournalKorean Journal of Veterinary Research
Volume61
Issue number1
DOIs
StatePublished - Mar 2021
Externally publishedYes

Keywords

  • Canine
  • Neoplasms
  • Palladia
  • Toceranib phosphate
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • veterinary(all)

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