Retransplantation after renal allograft loss due to noncompliance: Indications, outcome, and ethical concerns

Christoph Troppmann, E. Benedetti, R. W G Gruessner, W. D. Payne, D. E R Sutherland, J. S. Najarian, A. J. Matas

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Noncompliance is increasingly recognized as a major cause of renal allograft loss, but the results of retransplantation of such patients have never been described. At our center, 52 of 3525 kidney recipients between June 1, 1963 and December 31, 1993 lost their graft due to overt noncompliance. Of these, 14 (27%) underwent retransplantation after thorough interdisciplinary evaluation. All but 1 patient had returned to dialysis before retransplantation. Of the retransplanted grafts, 2 were lost (1 technical failure, 1 chronic rejection in a compliant patient); both recipients were retransplanted once again. Currently, all retransplanted patients are alive and have a functioning graft. We conclude that for selected patients with graft loss due to noncompliance excellent results can be achieved with retransplantation. However, the issue of retransplanting previously noncompliant patients in the face of a significant donor organ shortage requires public debate.

Original languageEnglish (US)
Pages (from-to)467-471
Number of pages5
JournalTransplantation
Volume59
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Allografts
Kidney
Transplants
Dialysis
Tissue Donors

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Troppmann, C., Benedetti, E., Gruessner, R. W. G., Payne, W. D., Sutherland, D. E. R., Najarian, J. S., & Matas, A. J. (1995). Retransplantation after renal allograft loss due to noncompliance: Indications, outcome, and ethical concerns. Transplantation, 59(4), 467-471.

Retransplantation after renal allograft loss due to noncompliance : Indications, outcome, and ethical concerns. / Troppmann, Christoph; Benedetti, E.; Gruessner, R. W G; Payne, W. D.; Sutherland, D. E R; Najarian, J. S.; Matas, A. J.

In: Transplantation, Vol. 59, No. 4, 1995, p. 467-471.

Research output: Contribution to journalArticle

Troppmann, C, Benedetti, E, Gruessner, RWG, Payne, WD, Sutherland, DER, Najarian, JS & Matas, AJ 1995, 'Retransplantation after renal allograft loss due to noncompliance: Indications, outcome, and ethical concerns', Transplantation, vol. 59, no. 4, pp. 467-471.
Troppmann C, Benedetti E, Gruessner RWG, Payne WD, Sutherland DER, Najarian JS et al. Retransplantation after renal allograft loss due to noncompliance: Indications, outcome, and ethical concerns. Transplantation. 1995;59(4):467-471.
Troppmann, Christoph ; Benedetti, E. ; Gruessner, R. W G ; Payne, W. D. ; Sutherland, D. E R ; Najarian, J. S. ; Matas, A. J. / Retransplantation after renal allograft loss due to noncompliance : Indications, outcome, and ethical concerns. In: Transplantation. 1995 ; Vol. 59, No. 4. pp. 467-471.
@article{be757e7e0b344df6add61d77df9215fa,
title = "Retransplantation after renal allograft loss due to noncompliance: Indications, outcome, and ethical concerns",
abstract = "Noncompliance is increasingly recognized as a major cause of renal allograft loss, but the results of retransplantation of such patients have never been described. At our center, 52 of 3525 kidney recipients between June 1, 1963 and December 31, 1993 lost their graft due to overt noncompliance. Of these, 14 (27{\%}) underwent retransplantation after thorough interdisciplinary evaluation. All but 1 patient had returned to dialysis before retransplantation. Of the retransplanted grafts, 2 were lost (1 technical failure, 1 chronic rejection in a compliant patient); both recipients were retransplanted once again. Currently, all retransplanted patients are alive and have a functioning graft. We conclude that for selected patients with graft loss due to noncompliance excellent results can be achieved with retransplantation. However, the issue of retransplanting previously noncompliant patients in the face of a significant donor organ shortage requires public debate.",
author = "Christoph Troppmann and E. Benedetti and Gruessner, {R. W G} and Payne, {W. D.} and Sutherland, {D. E R} and Najarian, {J. S.} and Matas, {A. J.}",
year = "1995",
language = "English (US)",
volume = "59",
pages = "467--471",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Retransplantation after renal allograft loss due to noncompliance

T2 - Indications, outcome, and ethical concerns

AU - Troppmann, Christoph

AU - Benedetti, E.

AU - Gruessner, R. W G

AU - Payne, W. D.

AU - Sutherland, D. E R

AU - Najarian, J. S.

AU - Matas, A. J.

PY - 1995

Y1 - 1995

N2 - Noncompliance is increasingly recognized as a major cause of renal allograft loss, but the results of retransplantation of such patients have never been described. At our center, 52 of 3525 kidney recipients between June 1, 1963 and December 31, 1993 lost their graft due to overt noncompliance. Of these, 14 (27%) underwent retransplantation after thorough interdisciplinary evaluation. All but 1 patient had returned to dialysis before retransplantation. Of the retransplanted grafts, 2 were lost (1 technical failure, 1 chronic rejection in a compliant patient); both recipients were retransplanted once again. Currently, all retransplanted patients are alive and have a functioning graft. We conclude that for selected patients with graft loss due to noncompliance excellent results can be achieved with retransplantation. However, the issue of retransplanting previously noncompliant patients in the face of a significant donor organ shortage requires public debate.

AB - Noncompliance is increasingly recognized as a major cause of renal allograft loss, but the results of retransplantation of such patients have never been described. At our center, 52 of 3525 kidney recipients between June 1, 1963 and December 31, 1993 lost their graft due to overt noncompliance. Of these, 14 (27%) underwent retransplantation after thorough interdisciplinary evaluation. All but 1 patient had returned to dialysis before retransplantation. Of the retransplanted grafts, 2 were lost (1 technical failure, 1 chronic rejection in a compliant patient); both recipients were retransplanted once again. Currently, all retransplanted patients are alive and have a functioning graft. We conclude that for selected patients with graft loss due to noncompliance excellent results can be achieved with retransplantation. However, the issue of retransplanting previously noncompliant patients in the face of a significant donor organ shortage requires public debate.

UR - http://www.scopus.com/inward/record.url?scp=0028966157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028966157&partnerID=8YFLogxK

M3 - Article

C2 - 7878747

AN - SCOPUS:0028966157

VL - 59

SP - 467

EP - 471

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 4

ER -