Retinopathy associated with ivermectin toxicosis in two dogs

Patrick J. Kenny, Karen Vernau, Birgit Puschner, David J Maggs

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Case Description - 2 dogs (dogs 1 and 2) were examined for sudden onset of blindness. Both dogs had mild obtundation and mydriasis In both eyes. It was thought that dog 1 may have ingested ivermectin; dog 2 had been treated with ivermectin for demodectic mange. Clinical Findings - On initial examination, both dogs had mydriasis and decreased pupillary light reflexes in both eyes. Dog 1 had an absent menace response bilaterally. Fundic examination of both eyes in both dogs revealed regions of multifocal retinal edema and folds with low-lying retinal separation.The electroretinogram was extinguished in dog 1 and attenuated In dog 2. Ivermectin was detected in serum samples from both dogs. Treatment and Outcome - Both dogs made a complete clinical recovery following cessation of exposure to ivermectin; electroretinographic findings improved, and retinal edema resolved with some residual chorioretinal scarring. Clinical Relevance - To our knowledge, this is the first report of resolution of retinal edema and electroretinographic changes associated with ivermectin toxicosis in dogs. In dogs that develop blindness suddenly, fundic examination, electroretinography, and assessment of serum ivermectin concentration are diagnostically useful, even if exposure to ivermectin is unknown.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalJournal of the American Veterinary Medical Association
Volume233
Issue number2
DOIs
StatePublished - Jul 15 2008

Fingerprint

retinal diseases
Ivermectin
ivermectin
poisoning
Dogs
dogs
Papilledema
edema
Mydriasis
electroretinography
blindness
eyes
Blindness
Pupillary Reflex
Mite Infestations
Electroretinography
mange
Abnormal Reflexes
Serum
reflexes

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Retinopathy associated with ivermectin toxicosis in two dogs. / Kenny, Patrick J.; Vernau, Karen; Puschner, Birgit; Maggs, David J.

In: Journal of the American Veterinary Medical Association, Vol. 233, No. 2, 15.07.2008, p. 279-284.

Research output: Contribution to journalArticle

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