Abstract
Case Description - 2 dogs (dogs 1 and 2) were examined for sudden onset of blindness. Both dogs had mild obtundation and mydriasis In both eyes. It was thought that dog 1 may have ingested ivermectin; dog 2 had been treated with ivermectin for demodectic mange. Clinical Findings - On initial examination, both dogs had mydriasis and decreased pupillary light reflexes in both eyes. Dog 1 had an absent menace response bilaterally. Fundic examination of both eyes in both dogs revealed regions of multifocal retinal edema and folds with low-lying retinal separation.The electroretinogram was extinguished in dog 1 and attenuated In dog 2. Ivermectin was detected in serum samples from both dogs. Treatment and Outcome - Both dogs made a complete clinical recovery following cessation of exposure to ivermectin; electroretinographic findings improved, and retinal edema resolved with some residual chorioretinal scarring. Clinical Relevance - To our knowledge, this is the first report of resolution of retinal edema and electroretinographic changes associated with ivermectin toxicosis in dogs. In dogs that develop blindness suddenly, fundic examination, electroretinography, and assessment of serum ivermectin concentration are diagnostically useful, even if exposure to ivermectin is unknown.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-284 |
| Number of pages | 6 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 233 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 15 2008 |
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ASJC Scopus subject areas
- veterinary(all)
Cite this
Retinopathy associated with ivermectin toxicosis in two dogs. / Kenny, Patrick J.; Vernau, Karen; Puschner, Birgit; Maggs, David J.
In: Journal of the American Veterinary Medical Association, Vol. 233, No. 2, 15.07.2008, p. 279-284.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retinopathy associated with ivermectin toxicosis in two dogs
AU - Kenny, Patrick J.
AU - Vernau, Karen
AU - Puschner, Birgit
AU - Maggs, David J
PY - 2008/7/15
Y1 - 2008/7/15
N2 - Case Description - 2 dogs (dogs 1 and 2) were examined for sudden onset of blindness. Both dogs had mild obtundation and mydriasis In both eyes. It was thought that dog 1 may have ingested ivermectin; dog 2 had been treated with ivermectin for demodectic mange. Clinical Findings - On initial examination, both dogs had mydriasis and decreased pupillary light reflexes in both eyes. Dog 1 had an absent menace response bilaterally. Fundic examination of both eyes in both dogs revealed regions of multifocal retinal edema and folds with low-lying retinal separation.The electroretinogram was extinguished in dog 1 and attenuated In dog 2. Ivermectin was detected in serum samples from both dogs. Treatment and Outcome - Both dogs made a complete clinical recovery following cessation of exposure to ivermectin; electroretinographic findings improved, and retinal edema resolved with some residual chorioretinal scarring. Clinical Relevance - To our knowledge, this is the first report of resolution of retinal edema and electroretinographic changes associated with ivermectin toxicosis in dogs. In dogs that develop blindness suddenly, fundic examination, electroretinography, and assessment of serum ivermectin concentration are diagnostically useful, even if exposure to ivermectin is unknown.
AB - Case Description - 2 dogs (dogs 1 and 2) were examined for sudden onset of blindness. Both dogs had mild obtundation and mydriasis In both eyes. It was thought that dog 1 may have ingested ivermectin; dog 2 had been treated with ivermectin for demodectic mange. Clinical Findings - On initial examination, both dogs had mydriasis and decreased pupillary light reflexes in both eyes. Dog 1 had an absent menace response bilaterally. Fundic examination of both eyes in both dogs revealed regions of multifocal retinal edema and folds with low-lying retinal separation.The electroretinogram was extinguished in dog 1 and attenuated In dog 2. Ivermectin was detected in serum samples from both dogs. Treatment and Outcome - Both dogs made a complete clinical recovery following cessation of exposure to ivermectin; electroretinographic findings improved, and retinal edema resolved with some residual chorioretinal scarring. Clinical Relevance - To our knowledge, this is the first report of resolution of retinal edema and electroretinographic changes associated with ivermectin toxicosis in dogs. In dogs that develop blindness suddenly, fundic examination, electroretinography, and assessment of serum ivermectin concentration are diagnostically useful, even if exposure to ivermectin is unknown.
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UR - http://www.scopus.com/inward/citedby.url?scp=48049086792&partnerID=8YFLogxK
U2 - 10.2460/javma.233.2.279
DO - 10.2460/javma.233.2.279
M3 - Article
VL - 233
SP - 279
EP - 284
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 2
ER -