Retinoid and thyroid hormone receptors: ligand-regulated transcription factors as proto-oncogenes.

M. L. Privalsky

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The retroviral v-erb A locus is derived from a cellular gene, c-erb A, encoding a thyroid hormone receptor. The v-erb A and c-erb A proteins are, in turn, members of a larger family of structurally and functionally interrelated polypeptides that includes the steroid, retinoic acid, and vitamin D3 receptors. These nuclear hormone receptors act by binding to specific sites on the cell genome and, in response to cognate hormone, modulating the transcription of adjacent 'target' genes. The expression, properties, and mechanisms of action of the thyroid hormone receptors (c-erb A proteins) and the closely related retinoic acid receptors are discussed.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalSeminars in Cell Biology
Volume3
Issue number2
StatePublished - Apr 1992

ASJC Scopus subject areas

  • Medicine(all)

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