Abstract
The retroviral v-erb A locus is derived from a cellular gene, c-erb A, encoding a thyroid hormone receptor. The v-erb A and c-erb A proteins are, in turn, members of a larger family of structurally and functionally interrelated polypeptides that includes the steroid, retinoic acid, and vitamin D3 receptors. These nuclear hormone receptors act by binding to specific sites on the cell genome and, in response to cognate hormone, modulating the transcription of adjacent 'target' genes. The expression, properties, and mechanisms of action of the thyroid hormone receptors (c-erb A proteins) and the closely related retinoic acid receptors are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 99-106 |
| Number of pages | 8 |
| Journal | Seminars in Cell Biology |
| Volume | 3 |
| Issue number | 2 |
| State | Published - Apr 1992 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Retinoid and thyroid hormone receptors : ligand-regulated transcription factors as proto-oncogenes. / Privalsky, M. L.
In: Seminars in Cell Biology, Vol. 3, No. 2, 04.1992, p. 99-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retinoid and thyroid hormone receptors
T2 - ligand-regulated transcription factors as proto-oncogenes.
AU - Privalsky, M. L.
PY - 1992/4
Y1 - 1992/4
N2 - The retroviral v-erb A locus is derived from a cellular gene, c-erb A, encoding a thyroid hormone receptor. The v-erb A and c-erb A proteins are, in turn, members of a larger family of structurally and functionally interrelated polypeptides that includes the steroid, retinoic acid, and vitamin D3 receptors. These nuclear hormone receptors act by binding to specific sites on the cell genome and, in response to cognate hormone, modulating the transcription of adjacent 'target' genes. The expression, properties, and mechanisms of action of the thyroid hormone receptors (c-erb A proteins) and the closely related retinoic acid receptors are discussed.
AB - The retroviral v-erb A locus is derived from a cellular gene, c-erb A, encoding a thyroid hormone receptor. The v-erb A and c-erb A proteins are, in turn, members of a larger family of structurally and functionally interrelated polypeptides that includes the steroid, retinoic acid, and vitamin D3 receptors. These nuclear hormone receptors act by binding to specific sites on the cell genome and, in response to cognate hormone, modulating the transcription of adjacent 'target' genes. The expression, properties, and mechanisms of action of the thyroid hormone receptors (c-erb A proteins) and the closely related retinoic acid receptors are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0026848499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026848499&partnerID=8YFLogxK
M3 - Article
C2 - 1319230
AN - SCOPUS:0026848499
VL - 3
SP - 99
EP - 106
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
IS - 2
ER -