Retinoic acid and microRNA

Lijun Wang, Atharva Piyush Rohatgi, Yu Jui Yvonne Wan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational repression. Like RA, miRNAs regulate multiple biological processes, including proliferation, differentiation, apoptosis, neurogenesis, tumorigenesis, and immunity. In fact, RA regulates the expression of many miRNAs to exert its biological functions. miRNA and RA regulatory networks have been studied in recent years. In this manuscript, we summarize literature that highlights the impact of miRNAs in RA-regulated molecular networks included in the PubMed.

Original languageEnglish (US)
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
DOIs
StateAccepted/In press - Jan 1 2020

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

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Keywords

  • Cancer
  • Development
  • Immunity
  • Inflammation
  • Metabolism
  • Neurological disease
  • Nuclear receptor
  • Regeneration
  • Retinoic acid receptor (RAR)
  • Retinoid X receptor (RXR)
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Wang, L., Rohatgi, A. P., & Wan, Y. J. Y. (Accepted/In press). Retinoic acid and microRNA. In Methods in Enzymology (Methods in Enzymology). Academic Press Inc.. https://doi.org/10.1016/bs.mie.2020.02.009