TY - CHAP
T1 - Retinoic acid and microRNA
AU - Wang, Lijun
AU - Rohatgi, Atharva Piyush
AU - Wan, Yu Jui Yvonne
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational repression. Like RA, miRNAs regulate multiple biological processes, including proliferation, differentiation, apoptosis, neurogenesis, tumorigenesis, and immunity. In fact, RA regulates the expression of many miRNAs to exert its biological functions. miRNA and RA regulatory networks have been studied in recent years. In this manuscript, we summarize literature that highlights the impact of miRNAs in RA-regulated molecular networks included in the PubMed.
AB - Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational repression. Like RA, miRNAs regulate multiple biological processes, including proliferation, differentiation, apoptosis, neurogenesis, tumorigenesis, and immunity. In fact, RA regulates the expression of many miRNAs to exert its biological functions. miRNA and RA regulatory networks have been studied in recent years. In this manuscript, we summarize literature that highlights the impact of miRNAs in RA-regulated molecular networks included in the PubMed.
KW - Cancer
KW - Development
KW - Immunity
KW - Inflammation
KW - Metabolism
KW - Neurological disease
KW - Nuclear receptor
KW - Regeneration
KW - Retinoic acid receptor (RAR)
KW - Retinoid X receptor (RXR)
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85082521068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082521068&partnerID=8YFLogxK
U2 - 10.1016/bs.mie.2020.02.009
DO - 10.1016/bs.mie.2020.02.009
M3 - Chapter
AN - SCOPUS:85082521068
T3 - Methods in Enzymology
BT - Methods in Enzymology
PB - Academic Press Inc.
ER -