Retinoic acid and microRNA

Lijun Wang; Atharva Piyush Rohatgi; Yu Jui Yvonne Wan

doi:10.1016/bs.mie.2020.02.009

Retinoic acid and microRNA

Lijun Wang, Atharva Piyush Rohatgi, Yu Jui Yvonne Wan

Pathology and Laboratory Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational repression. Like RA, miRNAs regulate multiple biological processes, including proliferation, differentiation, apoptosis, neurogenesis, tumorigenesis, and immunity. In fact, RA regulates the expression of many miRNAs to exert its biological functions. miRNA and RA regulatory networks have been studied in recent years. In this manuscript, we summarize literature that highlights the impact of miRNAs in RA-regulated molecular networks included in the PubMed.

Original language	English (US)
Title of host publication	Methods in Enzymology
Publisher	Academic Press Inc.
DOIs	https://doi.org/10.1016/bs.mie.2020.02.009
State	Accepted/In press - Jan 1 2020

Publication series

Name	Methods in Enzymology
ISSN (Print)	0076-6879
ISSN (Electronic)	1557-7988

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Keywords

Cancer
Development
Immunity
Inflammation
Metabolism
Neurological disease
Nuclear receptor
Regeneration
Retinoic acid receptor (RAR)
Retinoid X receptor (RXR)
Stem cells

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Cite this

Wang, L., Rohatgi, A. P., & Wan, Y. J. Y. (Accepted/In press). Retinoic acid and microRNA. In Methods in Enzymology (Methods in Enzymology). Academic Press Inc.. https://doi.org/10.1016/bs.mie.2020.02.009

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abstract = "Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational repression. Like RA, miRNAs regulate multiple biological processes, including proliferation, differentiation, apoptosis, neurogenesis, tumorigenesis, and immunity. In fact, RA regulates the expression of many miRNAs to exert its biological functions. miRNA and RA regulatory networks have been studied in recent years. In this manuscript, we summarize literature that highlights the impact of miRNAs in RA-regulated molecular networks included in the PubMed.",

keywords = "Cancer, Development, Immunity, Inflammation, Metabolism, Neurological disease, Nuclear receptor, Regeneration, Retinoic acid receptor (RAR), Retinoid X receptor (RXR), Stem cells",

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KW - Immunity

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KW - Metabolism

KW - Neurological disease

KW - Nuclear receptor

KW - Regeneration

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KW - Retinoid X receptor (RXR)

KW - Stem cells

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Access to Document

10.1016/bs.mie.2020.02.009