Retinal stem cells and regeneration

Ala Moshiri, Jennie Close, Thomas A. Reh

Research output: Contribution to journalArticle

124 Scopus citations

Abstract

The optic vesicle gives rise to several very different epithelial tissues, including the neural retina, the pigmented epithelium, the iris, the ciliary epithelium of the ciliary body and the optic stalk. Retinal regeneration can arise from several different cellular sources; in some species, the process involves interconversion, or transdifferentiation, among cells of the different tissue types. Therefore, prior to a discussion of retinal regeneration, we will briefly discuss current knowledge about the influence of signaling molecules in cell fate determination in ocular tissues. Next, we will detail the evidence for neurogenesis in the mature retina. Lastly, we will describe various types of regenerative phenomena that occur in the retina, from complete regeneration of functional retina in fish and amphibians, to the more limited neuronal production that occurs in avian and mammalian retinas.

Original languageEnglish (US)
Pages (from-to)1003-1014
Number of pages12
JournalInternational Journal of Developmental Biology
Volume48
Issue number8-9
DOIs
StatePublished - 2004
Externally publishedYes

Keywords

  • Müller
  • Neurogenesis
  • Optic
  • Progenitor
  • Stem cell

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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