Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics

Barry Cense, Weihua Gao, Jeffrey M. Brown, Steven M. Jones, Ravi Jonnal, Mircea Mujat, B. Hyle Park, Johannes F. De Boer, Donald T. Miller

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Various layers of the retina are well known to alter the polarization state of light. Such changes in polarization may be a sensitive indicator of tissue structure and function, and as such have gained increased clinical attention. Here we demonstrate a polarization-sensitive optical coherence tomography (PS-OCT) system that incorporates adaptive optics (AO) in the sample arm and a single line scan camera in the detection arm. We quantify the benefit of AO for PS-OCT in terms of signal-to-noise, lateral resolution, and speckle size. Double pass phase retardation per unit depth values ranging from 0.25°/μ m to 0.65°/μ m were found in the birefringent nerve fiber layer at 6° eccentricity, superior to the fovea, with the highest values being noticeably higher than previously reported with PSOCT around the optic nerve head. Moreover, fast axis orientation and degree of polarization uniformity measurements made with AO-PS-OCT demonstrate polarization scrambling in the retinal pigment epithelium at the highest resolution reported to date.

Original languageEnglish (US)
Pages (from-to)21634-21651
Number of pages18
JournalOptics Express
Volume17
Issue number24
DOIs
StatePublished - Nov 23 2009
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Cense, B., Gao, W., Brown, J. M., Jones, S. M., Jonnal, R., Mujat, M., Park, B. H., De Boer, J. F., & Miller, D. T. (2009). Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics. Optics Express, 17(24), 21634-21651. https://doi.org/10.1364/OE.17.021634