Retinal imaging with a combined adaptive optics - Optical coherence tomography and adaptive optics - Scanning laser ophthalmoscopy system

Robert Zawadzki, Steven M. Jones, Suman Pilli, Dae Yu Kim, Scot S. Olivier, John S Werner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations


We describe results of retinal imaging with a novel instrument that combines adaptive optics - Fourier-domain optical coherence tomography (AO-OCT) with an adaptive optics scanning laser ophthalmoscope (AO-SLO). One of the benefits of combining Fd-OCT with SLO includes automatic co-registration between the two imaging modalities and the potential for correcting lateral and transversal eye motion resulting in motion artifact-free volumetric retinal imaging. Additionally this allows for direct comparison between retinal structures that can be imaged with both modalities (e.g., photoreceptor mosaics or microvasculature maps). This dual imaging modality could provide insight into some retinal properties that could not be accessed by a single imaging system. Additionally, extension of OCT and SLO beyond structural imaging may open new avenues for diagnostics and testing in ophthalmology. In particular, non-invasive vasculature mapping with these modalities holds promise of replacing fluorescein angiography in vascular identification. Several new improvements of our system are described, including results of testing a novel 97-actuator deformable mirror and AO-SLO light intensity modulation.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2010
EventOphthalmic Technologies XX - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010


OtherOphthalmic Technologies XX
Country/TerritoryUnited States
CitySan Francisco, CA


  • Aberration compensation
  • Adaptive optics
  • Imaging system
  • Medical optics instrumentation
  • Ophthalmology
  • Optical coherence tomography
  • Scanning laser ophthalmoscopy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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