Retinal AO OCT

Robert Zawadzki, Donald T. Miller

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


The last two decades have witnessed extraordinary advances in optical technology to image noninvasively and at high resolution the posterior segment of the eye. Two of the most impactful technological advancements over this period have arguably been optical coherence tomography (OCT) and adaptive optics (AO). The strengths of these technologies complement each other and when combined have been shown to provide unprecedented, micron-scale resolution (<3 μm) in all three dimensions and sensitivity to image the cellular retina in the living eye. This powerful extension of OCT, that is AO-OCT, is the focus of this chapter. It presents key aspects of designing and implementing AO-OCT systems. Particular attention is devoted to the relevant optical properties of the eye that ultimately define these systems, AO componentry and operation tailored for ophthalmic use, and of course use of the latest technologies and methods in OCT for ocular imaging. It surveys the wide range of AO-OCT designs that have been developed for retinal imaging, with AO integrated into every major OCT design configuration. Finally, it reviews the scientific and clinical studies reported to date that show the exciting potential of AO-OCT to image the microscopic retina and fundus in ways not previously possible with other noninvasive methods and a look to future developments in this rapidly growing field.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography
Subtitle of host publicationTechnology and Applications, Second Edition
PublisherSpringer International Publishing
Number of pages72
ISBN (Electronic)9783319064192
ISBN (Print)9783319064185
StatePublished - Jan 1 2015


  • adaptive optics
  • age-related macular degeneration
  • choroidal vasculature
  • color blindness phenotyping
  • eye
  • glaucoma
  • image quality of the eye
  • image registration
  • macular telangiectasia
  • medical optics instrumentation
  • Microscopy
  • Monochromatic and chromatic aberrations
  • motion artifact correction
  • non-invasive assessment of the visual system
  • ocular aberrations
  • ophthalmic optics
  • Ophthalmology
  • Optic nerve head
  • Optic neuropathies
  • Optical biopsy
  • Optical coherence tomography
  • Phase-sensitive AO-OCT
  • photoreceptors
  • Polarization-sensitive AO-OCT
  • retina
  • retinal nerve fiber layer
  • retinal pigment epithelium
  • retinal vasculature
  • retinitis pigmentosa
  • retinopathy of prematurity
  • wavefront corrector
  • wavefront sensor

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)


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