Retention and distribution of iron added to cow's milk and human milk as various salts and chelates

R. O. Kwock, Carl L Keen, J. Hegenauer, P. Saltman, L. S. Hurley, B. Lönnerdal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Iron supplementation of infant formulas is recommended by most national and international organizations, but the optimal form of supplementation has not been determined. We have compared the bioavailability and tissue distribution of iron from four iron chelates and two commonly used iron salts. Weanling C57BL/6J mice were fed for 1 week an evaporated cow's milk diet supplemented with vitamins and minerals (except for iron). Following the adjustment period, mice were divided into 2 groups of 20 each. Six groups continued to receive cow's milk diet for 18 hours, while the other six groups were fed a similar diet based on human milk. Individual groups received a single dose of milk radioactively labeled with Fe(II)Cl2, Fe(II)SO4, Fe(III)NTA, Fe(III)EDTA, Fe(III)citrate or Fe(III)lactobionate. Wholebody retention was measured after 4 days; animals were then killed and individual tissues were counted for radioactivity. Iron from FeCl2, FeSO4 and FeNTA were the best retained from both milk diets. Fe citrate had a significantly lower iron retention than all other groups in either diet and is probably not an effective chelate for delivering iron to milk diets. Iron bioavailability was higher from the human milk diets than from the cow's milk diets from all vehicles used except citrate and lactobionate. Absorption of Fe citrate was similar from the two milk diets, while percent retention from Fa lactobionate was higher from cow's milk than from human milk. Tissue distribution of retained iron was similar for the milk diets and among the groups, indicating that, once absorbed, iron from the different vehicles is metabolized in a similar manner.

Original languageEnglish (US)
Pages (from-to)1454-1461
Number of pages8
JournalJournal of Nutrition
Volume114
Issue number8
StatePublished - 1984

Fingerprint

chelates
Human Milk
breast milk
Milk
Iron
Salts
iron
Diet
salts
milk
diet
Citric Acid
citrates
Iron Chelating Agents
Tissue Distribution
tissue distribution
Biological Availability
bioavailability
Infant Formula
international organizations

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Kwock, R. O., Keen, C. L., Hegenauer, J., Saltman, P., Hurley, L. S., & Lönnerdal, B. (1984). Retention and distribution of iron added to cow's milk and human milk as various salts and chelates. Journal of Nutrition, 114(8), 1454-1461.

Retention and distribution of iron added to cow's milk and human milk as various salts and chelates. / Kwock, R. O.; Keen, Carl L; Hegenauer, J.; Saltman, P.; Hurley, L. S.; Lönnerdal, B.

In: Journal of Nutrition, Vol. 114, No. 8, 1984, p. 1454-1461.

Research output: Contribution to journalArticle

Kwock, RO, Keen, CL, Hegenauer, J, Saltman, P, Hurley, LS & Lönnerdal, B 1984, 'Retention and distribution of iron added to cow's milk and human milk as various salts and chelates', Journal of Nutrition, vol. 114, no. 8, pp. 1454-1461.
Kwock RO, Keen CL, Hegenauer J, Saltman P, Hurley LS, Lönnerdal B. Retention and distribution of iron added to cow's milk and human milk as various salts and chelates. Journal of Nutrition. 1984;114(8):1454-1461.
Kwock, R. O. ; Keen, Carl L ; Hegenauer, J. ; Saltman, P. ; Hurley, L. S. ; Lönnerdal, B. / Retention and distribution of iron added to cow's milk and human milk as various salts and chelates. In: Journal of Nutrition. 1984 ; Vol. 114, No. 8. pp. 1454-1461.
@article{826b2d41eab44616962fc9ad8599e289,
title = "Retention and distribution of iron added to cow's milk and human milk as various salts and chelates",
abstract = "Iron supplementation of infant formulas is recommended by most national and international organizations, but the optimal form of supplementation has not been determined. We have compared the bioavailability and tissue distribution of iron from four iron chelates and two commonly used iron salts. Weanling C57BL/6J mice were fed for 1 week an evaporated cow's milk diet supplemented with vitamins and minerals (except for iron). Following the adjustment period, mice were divided into 2 groups of 20 each. Six groups continued to receive cow's milk diet for 18 hours, while the other six groups were fed a similar diet based on human milk. Individual groups received a single dose of milk radioactively labeled with Fe(II)Cl2, Fe(II)SO4, Fe(III)NTA, Fe(III)EDTA, Fe(III)citrate or Fe(III)lactobionate. Wholebody retention was measured after 4 days; animals were then killed and individual tissues were counted for radioactivity. Iron from FeCl2, FeSO4 and FeNTA were the best retained from both milk diets. Fe citrate had a significantly lower iron retention than all other groups in either diet and is probably not an effective chelate for delivering iron to milk diets. Iron bioavailability was higher from the human milk diets than from the cow's milk diets from all vehicles used except citrate and lactobionate. Absorption of Fe citrate was similar from the two milk diets, while percent retention from Fa lactobionate was higher from cow's milk than from human milk. Tissue distribution of retained iron was similar for the milk diets and among the groups, indicating that, once absorbed, iron from the different vehicles is metabolized in a similar manner.",
author = "Kwock, {R. O.} and Keen, {Carl L} and J. Hegenauer and P. Saltman and Hurley, {L. S.} and B. L{\"o}nnerdal",
year = "1984",
language = "English (US)",
volume = "114",
pages = "1454--1461",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "8",

}

TY - JOUR

T1 - Retention and distribution of iron added to cow's milk and human milk as various salts and chelates

AU - Kwock, R. O.

AU - Keen, Carl L

AU - Hegenauer, J.

AU - Saltman, P.

AU - Hurley, L. S.

AU - Lönnerdal, B.

PY - 1984

Y1 - 1984

N2 - Iron supplementation of infant formulas is recommended by most national and international organizations, but the optimal form of supplementation has not been determined. We have compared the bioavailability and tissue distribution of iron from four iron chelates and two commonly used iron salts. Weanling C57BL/6J mice were fed for 1 week an evaporated cow's milk diet supplemented with vitamins and minerals (except for iron). Following the adjustment period, mice were divided into 2 groups of 20 each. Six groups continued to receive cow's milk diet for 18 hours, while the other six groups were fed a similar diet based on human milk. Individual groups received a single dose of milk radioactively labeled with Fe(II)Cl2, Fe(II)SO4, Fe(III)NTA, Fe(III)EDTA, Fe(III)citrate or Fe(III)lactobionate. Wholebody retention was measured after 4 days; animals were then killed and individual tissues were counted for radioactivity. Iron from FeCl2, FeSO4 and FeNTA were the best retained from both milk diets. Fe citrate had a significantly lower iron retention than all other groups in either diet and is probably not an effective chelate for delivering iron to milk diets. Iron bioavailability was higher from the human milk diets than from the cow's milk diets from all vehicles used except citrate and lactobionate. Absorption of Fe citrate was similar from the two milk diets, while percent retention from Fa lactobionate was higher from cow's milk than from human milk. Tissue distribution of retained iron was similar for the milk diets and among the groups, indicating that, once absorbed, iron from the different vehicles is metabolized in a similar manner.

AB - Iron supplementation of infant formulas is recommended by most national and international organizations, but the optimal form of supplementation has not been determined. We have compared the bioavailability and tissue distribution of iron from four iron chelates and two commonly used iron salts. Weanling C57BL/6J mice were fed for 1 week an evaporated cow's milk diet supplemented with vitamins and minerals (except for iron). Following the adjustment period, mice were divided into 2 groups of 20 each. Six groups continued to receive cow's milk diet for 18 hours, while the other six groups were fed a similar diet based on human milk. Individual groups received a single dose of milk radioactively labeled with Fe(II)Cl2, Fe(II)SO4, Fe(III)NTA, Fe(III)EDTA, Fe(III)citrate or Fe(III)lactobionate. Wholebody retention was measured after 4 days; animals were then killed and individual tissues were counted for radioactivity. Iron from FeCl2, FeSO4 and FeNTA were the best retained from both milk diets. Fe citrate had a significantly lower iron retention than all other groups in either diet and is probably not an effective chelate for delivering iron to milk diets. Iron bioavailability was higher from the human milk diets than from the cow's milk diets from all vehicles used except citrate and lactobionate. Absorption of Fe citrate was similar from the two milk diets, while percent retention from Fa lactobionate was higher from cow's milk than from human milk. Tissue distribution of retained iron was similar for the milk diets and among the groups, indicating that, once absorbed, iron from the different vehicles is metabolized in a similar manner.

UR - http://www.scopus.com/inward/record.url?scp=0021209695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021209695&partnerID=8YFLogxK

M3 - Article

VL - 114

SP - 1454

EP - 1461

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 8

ER -