Retarding Novikoff tumor growth by altering host rat cholesterol metabolism

Philip D Schneider, Eve K. Chan, Ignacio J. Guzman, Richard D. Rucker, Richard L. Varco, Henry Buchwald

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Tumor cells, in vitro, must derive the majority of their required cholesterol from their host milieu. To determine if limiting tumor-available cholesterol results in limited tumor growth in vivo, Holtzman rats were given 10 × 106 Novikoff ascites tumor cells subcutaneously. Prior to inoculation, animals received either distal small bowel exclusion or sham operation plus either standard chow or estrone-containing chow (0.0025% or 0.01%) diets. In three separate experiments it was shown that (1) tumor weight was positively correlated with whole plasma cholesterol levels (r = 0.495; P < 0.05); (2) the lowest tumor weights were correlated with the lowest plasma cholesterol; (3) low density and very low density lipoprotein cholesterol levels were both individually and in combination positively correlated with tumor weight (2R = 0.828; P < 0.01); and (4) survival of subcutaneous tumor inoculated animals was significantly greater in those animals shown to have the lowest plasma cholesterol, 27 ± 1 days versus 29 ± 1 days; (P < 0.05). These data support the concept that limiting tumor-available cholesterol by altering host cholesterol metabolism will limit tumor growth.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalSurgery
Volume87
Issue number4
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Schneider, P. D., Chan, E. K., Guzman, I. J., Rucker, R. D., Varco, R. L., & Buchwald, H. (1980). Retarding Novikoff tumor growth by altering host rat cholesterol metabolism. Surgery, 87(4), 409-416.