Abstract
Tumor cells, in vitro, must derive the majority of their required cholesterol from their host milieu. To determine if limiting tumor-available cholesterol results in limited tumor growth in vivo, Holtzman rats were given 10 × 106 Novikoff ascites tumor cells subcutaneously. Prior to inoculation, animals received either distal small bowel exclusion or sham operation plus either standard chow or estrone-containing chow (0.0025% or 0.01%) diets. In three separate experiments it was shown that (1) tumor weight was positively correlated with whole plasma cholesterol levels (r = 0.495; P < 0.05); (2) the lowest tumor weights were correlated with the lowest plasma cholesterol; (3) low density and very low density lipoprotein cholesterol levels were both individually and in combination positively correlated with tumor weight (2R = 0.828; P < 0.01); and (4) survival of subcutaneous tumor inoculated animals was significantly greater in those animals shown to have the lowest plasma cholesterol, 27 ± 1 days versus 29 ± 1 days; (P < 0.05). These data support the concept that limiting tumor-available cholesterol by altering host cholesterol metabolism will limit tumor growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 409-416 |
| Number of pages | 8 |
| Journal | Surgery |
| Volume | 87 |
| Issue number | 4 |
| State | Published - 1980 |
| Externally published | Yes |
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- Surgery
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Retarding Novikoff tumor growth by altering host rat cholesterol metabolism. / Schneider, Philip D; Chan, Eve K.; Guzman, Ignacio J.; Rucker, Richard D.; Varco, Richard L.; Buchwald, Henry.
In: Surgery, Vol. 87, No. 4, 1980, p. 409-416.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retarding Novikoff tumor growth by altering host rat cholesterol metabolism
AU - Schneider, Philip D
AU - Chan, Eve K.
AU - Guzman, Ignacio J.
AU - Rucker, Richard D.
AU - Varco, Richard L.
AU - Buchwald, Henry
PY - 1980
Y1 - 1980
N2 - Tumor cells, in vitro, must derive the majority of their required cholesterol from their host milieu. To determine if limiting tumor-available cholesterol results in limited tumor growth in vivo, Holtzman rats were given 10 × 106 Novikoff ascites tumor cells subcutaneously. Prior to inoculation, animals received either distal small bowel exclusion or sham operation plus either standard chow or estrone-containing chow (0.0025% or 0.01%) diets. In three separate experiments it was shown that (1) tumor weight was positively correlated with whole plasma cholesterol levels (r = 0.495; P < 0.05); (2) the lowest tumor weights were correlated with the lowest plasma cholesterol; (3) low density and very low density lipoprotein cholesterol levels were both individually and in combination positively correlated with tumor weight (2R = 0.828; P < 0.01); and (4) survival of subcutaneous tumor inoculated animals was significantly greater in those animals shown to have the lowest plasma cholesterol, 27 ± 1 days versus 29 ± 1 days; (P < 0.05). These data support the concept that limiting tumor-available cholesterol by altering host cholesterol metabolism will limit tumor growth.
AB - Tumor cells, in vitro, must derive the majority of their required cholesterol from their host milieu. To determine if limiting tumor-available cholesterol results in limited tumor growth in vivo, Holtzman rats were given 10 × 106 Novikoff ascites tumor cells subcutaneously. Prior to inoculation, animals received either distal small bowel exclusion or sham operation plus either standard chow or estrone-containing chow (0.0025% or 0.01%) diets. In three separate experiments it was shown that (1) tumor weight was positively correlated with whole plasma cholesterol levels (r = 0.495; P < 0.05); (2) the lowest tumor weights were correlated with the lowest plasma cholesterol; (3) low density and very low density lipoprotein cholesterol levels were both individually and in combination positively correlated with tumor weight (2R = 0.828; P < 0.01); and (4) survival of subcutaneous tumor inoculated animals was significantly greater in those animals shown to have the lowest plasma cholesterol, 27 ± 1 days versus 29 ± 1 days; (P < 0.05). These data support the concept that limiting tumor-available cholesterol by altering host cholesterol metabolism will limit tumor growth.
UR - http://www.scopus.com/inward/record.url?scp=0018895735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018895735&partnerID=8YFLogxK
M3 - Article
C2 - 7368085
AN - SCOPUS:0018895735
VL - 87
SP - 409
EP - 416
JO - Surgery (United States)
JF - Surgery (United States)
SN - 0039-6060
IS - 4
ER -