Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility

Alison Van Eenennaam, Holly Neibergs, Christopher Seabury, Jeremy Taylor, Zeping Wang, Erik Scraggs, Robert D. Schnabel, Jared Decker, Andrzej Wojtowicz, Sharif S Aly, Jessica Davis, Patricia C Blanchard, Beate Crossley, Paul Rossitto, Terry W Lehenbauer, Robert Hagevoort, Erik Chavez, J. Shannon Neibergs, James E. Womack

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17-20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalAnimal health research reviews / Conference of Research Workers in Animal Diseases
Volume15
Issue number2
DOIs
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Van Eenennaam, A., Neibergs, H., Seabury, C., Taylor, J., Wang, Z., Scraggs, E., Schnabel, R. D., Decker, J., Wojtowicz, A., Aly, S. S., Davis, J., Blanchard, P. C., Crossley, B., Rossitto, P., Lehenbauer, T. W., Hagevoort, R., Chavez, E., Neibergs, J. S., & Womack, J. E. (2014). Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility. Animal health research reviews / Conference of Research Workers in Animal Diseases, 15(2), 157-160. https://doi.org/10.1017/S1466252314000231