Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility

Alison Van Eenennaam, Holly Neibergs, Christopher Seabury, Jeremy Taylor, Zeping Wang, Erik Scraggs, Robert D. Schnabel, Jared Decker, Andrzej Wojtowicz, Sharif S Aly, Jessica Davis, Patricia C Blanchard, Beate Crossley, Paul Rossitto, Terry W Lehenbauer, Robert Hagevoort, Erik Chavez, J. Shannon Neibergs, James E. Womack

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17-20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalAnimal health research reviews / Conference of Research Workers in Animal Diseases
Volume15
Issue number2
DOIs
StatePublished - Dec 1 2014

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Cattle Diseases
bovine respiratory disease
Genetic Markers
Genome-Wide Association Study
Single Nucleotide Polymorphism
genetic markers
United States Department of Agriculture
Chromosome Mapping
Genetic Predisposition to Disease
dairy calves
Genomics
cattle
Incidence
Health
dairy heifers
feedlots
USDA
beef cattle
single nucleotide polymorphism
chromosome mapping

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Results of the BRD CAP project : progress toward identifying genetic markers associated with BRD susceptibility. / Van Eenennaam, Alison; Neibergs, Holly; Seabury, Christopher; Taylor, Jeremy; Wang, Zeping; Scraggs, Erik; Schnabel, Robert D.; Decker, Jared; Wojtowicz, Andrzej; Aly, Sharif S; Davis, Jessica; Blanchard, Patricia C; Crossley, Beate; Rossitto, Paul; Lehenbauer, Terry W; Hagevoort, Robert; Chavez, Erik; Neibergs, J. Shannon; Womack, James E.

In: Animal health research reviews / Conference of Research Workers in Animal Diseases, Vol. 15, No. 2, 01.12.2014, p. 157-160.

Research output: Contribution to journalArticle

Van Eenennaam, A, Neibergs, H, Seabury, C, Taylor, J, Wang, Z, Scraggs, E, Schnabel, RD, Decker, J, Wojtowicz, A, Aly, SS, Davis, J, Blanchard, PC, Crossley, B, Rossitto, P, Lehenbauer, TW, Hagevoort, R, Chavez, E, Neibergs, JS & Womack, JE 2014, 'Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility', Animal health research reviews / Conference of Research Workers in Animal Diseases, vol. 15, no. 2, pp. 157-160. https://doi.org/10.1017/S1466252314000231
Van Eenennaam, Alison ; Neibergs, Holly ; Seabury, Christopher ; Taylor, Jeremy ; Wang, Zeping ; Scraggs, Erik ; Schnabel, Robert D. ; Decker, Jared ; Wojtowicz, Andrzej ; Aly, Sharif S ; Davis, Jessica ; Blanchard, Patricia C ; Crossley, Beate ; Rossitto, Paul ; Lehenbauer, Terry W ; Hagevoort, Robert ; Chavez, Erik ; Neibergs, J. Shannon ; Womack, James E. / Results of the BRD CAP project : progress toward identifying genetic markers associated with BRD susceptibility. In: Animal health research reviews / Conference of Research Workers in Animal Diseases. 2014 ; Vol. 15, No. 2. pp. 157-160.
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