Abstract
The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17-20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 157-160 |
| Number of pages | 4 |
| Journal | Animal health research reviews / Conference of Research Workers in Animal Diseases |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1 2014 |
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ASJC Scopus subject areas
- Medicine(all)
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Results of the BRD CAP project : progress toward identifying genetic markers associated with BRD susceptibility. / Van Eenennaam, Alison; Neibergs, Holly; Seabury, Christopher; Taylor, Jeremy; Wang, Zeping; Scraggs, Erik; Schnabel, Robert D.; Decker, Jared; Wojtowicz, Andrzej; Aly, Sharif S; Davis, Jessica; Blanchard, Patricia C; Crossley, Beate; Rossitto, Paul; Lehenbauer, Terry W; Hagevoort, Robert; Chavez, Erik; Neibergs, J. Shannon; Womack, James E.
In: Animal health research reviews / Conference of Research Workers in Animal Diseases, Vol. 15, No. 2, 01.12.2014, p. 157-160.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Results of the BRD CAP project
T2 - progress toward identifying genetic markers associated with BRD susceptibility
AU - Van Eenennaam, Alison
AU - Neibergs, Holly
AU - Seabury, Christopher
AU - Taylor, Jeremy
AU - Wang, Zeping
AU - Scraggs, Erik
AU - Schnabel, Robert D.
AU - Decker, Jared
AU - Wojtowicz, Andrzej
AU - Aly, Sharif S
AU - Davis, Jessica
AU - Blanchard, Patricia C
AU - Crossley, Beate
AU - Rossitto, Paul
AU - Lehenbauer, Terry W
AU - Hagevoort, Robert
AU - Chavez, Erik
AU - Neibergs, J. Shannon
AU - Womack, James E.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17-20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations.
AB - The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17-20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations.
UR - http://www.scopus.com/inward/record.url?scp=84929023760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929023760&partnerID=8YFLogxK
U2 - 10.1017/S1466252314000231
DO - 10.1017/S1466252314000231
M3 - Article
C2 - 25384903
AN - SCOPUS:84929023760
VL - 15
SP - 157
EP - 160
JO - Animal Health Research Reviews
JF - Animal Health Research Reviews
SN - 1466-2523
IS - 2
ER -