Rest-activity patterns and falls and fractures in older men

Tara S. Rogers, Terri L. Blackwell, Nancy E Lane, Greg Tranah, Eric S. Orwoll, Jane A. Cauley, Sonia Ancoli-Israel, Katie L. Stone, Steven R. Cummings, Peggy M. Cawthon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Summary: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. Purpose: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men. We hypothesized that dysregulated RAR would be associated with incident falls/fractures. Methods: We used wrist-worn actigraphy to measure RAR over 4.8 ± 0.8 24-h periods in men (≥67 years) enrolled in the multicenter Outcomes of Sleep Disorders in Men (MrOS Sleep) Study (n = 3001). Men were contacted every 4 months to report occurrence of falls/fractures. RAR parameters included amplitude (difference between peak and nadir activity in counts/minute), mesor (activity counts/minute), acrophase (time of day of peak activity), and pseudo-F statistic (rhythm robustness) and were evaluated as continuous variables with associations reported per SD increase/decrease in models adjusted for confounders. Logistic regression was used to estimate the likelihood (odds ratio, OR) of recurrent falls in the year after the visit. Proportional hazards models were used to estimate the risk (hazard ratio, HR) of fractures. Results: One year after the visit, 417 men (14%) had recurrent (≥2) falls. Later acrophase (OR 1.18, 95% CI 1.06–1.32) was associated with a modestly greater likelihood of falls. In 8.6 years (SD 2.6 years) of >97% complete follow-up, 256 men (8.53%) had a major osteoporotic fracture, 85 (2.8%) had a clinical spine fracture, and 110 (3.7%) had a hip fracture. No consistent, significant associations were observed between RAR patterns and fractures. Conclusions: Later acrophase was associated with a modestly greater risk of falls; this association did not translate into a higher fracture risk in this cohort of elderly men.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalOsteoporosis International
DOIs
StateAccepted/In press - Dec 24 2016

Fingerprint

Odds Ratio
Actigraphy
Osteoporotic Fractures
Hip Fractures
Wrist
Proportional Hazards Models
Osteoporosis
Spine
Logistic Models
Health
Sleep Wake Disorders

Keywords

  • Aging
  • Epidemiology
  • Falls
  • Fractures
  • Rest-activity rhythm

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Rogers, T. S., Blackwell, T. L., Lane, N. E., Tranah, G., Orwoll, E. S., Cauley, J. A., ... Cawthon, P. M. (Accepted/In press). Rest-activity patterns and falls and fractures in older men. Osteoporosis International, 1-10. https://doi.org/10.1007/s00198-016-3874-2

Rest-activity patterns and falls and fractures in older men. / Rogers, Tara S.; Blackwell, Terri L.; Lane, Nancy E; Tranah, Greg; Orwoll, Eric S.; Cauley, Jane A.; Ancoli-Israel, Sonia; Stone, Katie L.; Cummings, Steven R.; Cawthon, Peggy M.

In: Osteoporosis International, 24.12.2016, p. 1-10.

Research output: Contribution to journalArticle

Rogers, TS, Blackwell, TL, Lane, NE, Tranah, G, Orwoll, ES, Cauley, JA, Ancoli-Israel, S, Stone, KL, Cummings, SR & Cawthon, PM 2016, 'Rest-activity patterns and falls and fractures in older men', Osteoporosis International, pp. 1-10. https://doi.org/10.1007/s00198-016-3874-2
Rogers, Tara S. ; Blackwell, Terri L. ; Lane, Nancy E ; Tranah, Greg ; Orwoll, Eric S. ; Cauley, Jane A. ; Ancoli-Israel, Sonia ; Stone, Katie L. ; Cummings, Steven R. ; Cawthon, Peggy M. / Rest-activity patterns and falls and fractures in older men. In: Osteoporosis International. 2016 ; pp. 1-10.
@article{9b559045afcb4793a0f0971345916305,
title = "Rest-activity patterns and falls and fractures in older men",
abstract = "Summary: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. Purpose: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men. We hypothesized that dysregulated RAR would be associated with incident falls/fractures. Methods: We used wrist-worn actigraphy to measure RAR over 4.8 ± 0.8 24-h periods in men (≥67 years) enrolled in the multicenter Outcomes of Sleep Disorders in Men (MrOS Sleep) Study (n = 3001). Men were contacted every 4 months to report occurrence of falls/fractures. RAR parameters included amplitude (difference between peak and nadir activity in counts/minute), mesor (activity counts/minute), acrophase (time of day of peak activity), and pseudo-F statistic (rhythm robustness) and were evaluated as continuous variables with associations reported per SD increase/decrease in models adjusted for confounders. Logistic regression was used to estimate the likelihood (odds ratio, OR) of recurrent falls in the year after the visit. Proportional hazards models were used to estimate the risk (hazard ratio, HR) of fractures. Results: One year after the visit, 417 men (14{\%}) had recurrent (≥2) falls. Later acrophase (OR 1.18, 95{\%} CI 1.06–1.32) was associated with a modestly greater likelihood of falls. In 8.6 years (SD 2.6 years) of >97{\%} complete follow-up, 256 men (8.53{\%}) had a major osteoporotic fracture, 85 (2.8{\%}) had a clinical spine fracture, and 110 (3.7{\%}) had a hip fracture. No consistent, significant associations were observed between RAR patterns and fractures. Conclusions: Later acrophase was associated with a modestly greater risk of falls; this association did not translate into a higher fracture risk in this cohort of elderly men.",
keywords = "Aging, Epidemiology, Falls, Fractures, Rest-activity rhythm",
author = "Rogers, {Tara S.} and Blackwell, {Terri L.} and Lane, {Nancy E} and Greg Tranah and Orwoll, {Eric S.} and Cauley, {Jane A.} and Sonia Ancoli-Israel and Stone, {Katie L.} and Cummings, {Steven R.} and Cawthon, {Peggy M.}",
year = "2016",
month = "12",
day = "24",
doi = "10.1007/s00198-016-3874-2",
language = "English (US)",
pages = "1--10",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",

}

TY - JOUR

T1 - Rest-activity patterns and falls and fractures in older men

AU - Rogers, Tara S.

AU - Blackwell, Terri L.

AU - Lane, Nancy E

AU - Tranah, Greg

AU - Orwoll, Eric S.

AU - Cauley, Jane A.

AU - Ancoli-Israel, Sonia

AU - Stone, Katie L.

AU - Cummings, Steven R.

AU - Cawthon, Peggy M.

PY - 2016/12/24

Y1 - 2016/12/24

N2 - Summary: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. Purpose: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men. We hypothesized that dysregulated RAR would be associated with incident falls/fractures. Methods: We used wrist-worn actigraphy to measure RAR over 4.8 ± 0.8 24-h periods in men (≥67 years) enrolled in the multicenter Outcomes of Sleep Disorders in Men (MrOS Sleep) Study (n = 3001). Men were contacted every 4 months to report occurrence of falls/fractures. RAR parameters included amplitude (difference between peak and nadir activity in counts/minute), mesor (activity counts/minute), acrophase (time of day of peak activity), and pseudo-F statistic (rhythm robustness) and were evaluated as continuous variables with associations reported per SD increase/decrease in models adjusted for confounders. Logistic regression was used to estimate the likelihood (odds ratio, OR) of recurrent falls in the year after the visit. Proportional hazards models were used to estimate the risk (hazard ratio, HR) of fractures. Results: One year after the visit, 417 men (14%) had recurrent (≥2) falls. Later acrophase (OR 1.18, 95% CI 1.06–1.32) was associated with a modestly greater likelihood of falls. In 8.6 years (SD 2.6 years) of >97% complete follow-up, 256 men (8.53%) had a major osteoporotic fracture, 85 (2.8%) had a clinical spine fracture, and 110 (3.7%) had a hip fracture. No consistent, significant associations were observed between RAR patterns and fractures. Conclusions: Later acrophase was associated with a modestly greater risk of falls; this association did not translate into a higher fracture risk in this cohort of elderly men.

AB - Summary: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. Purpose: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men. We hypothesized that dysregulated RAR would be associated with incident falls/fractures. Methods: We used wrist-worn actigraphy to measure RAR over 4.8 ± 0.8 24-h periods in men (≥67 years) enrolled in the multicenter Outcomes of Sleep Disorders in Men (MrOS Sleep) Study (n = 3001). Men were contacted every 4 months to report occurrence of falls/fractures. RAR parameters included amplitude (difference between peak and nadir activity in counts/minute), mesor (activity counts/minute), acrophase (time of day of peak activity), and pseudo-F statistic (rhythm robustness) and were evaluated as continuous variables with associations reported per SD increase/decrease in models adjusted for confounders. Logistic regression was used to estimate the likelihood (odds ratio, OR) of recurrent falls in the year after the visit. Proportional hazards models were used to estimate the risk (hazard ratio, HR) of fractures. Results: One year after the visit, 417 men (14%) had recurrent (≥2) falls. Later acrophase (OR 1.18, 95% CI 1.06–1.32) was associated with a modestly greater likelihood of falls. In 8.6 years (SD 2.6 years) of >97% complete follow-up, 256 men (8.53%) had a major osteoporotic fracture, 85 (2.8%) had a clinical spine fracture, and 110 (3.7%) had a hip fracture. No consistent, significant associations were observed between RAR patterns and fractures. Conclusions: Later acrophase was associated with a modestly greater risk of falls; this association did not translate into a higher fracture risk in this cohort of elderly men.

KW - Aging

KW - Epidemiology

KW - Falls

KW - Fractures

KW - Rest-activity rhythm

UR - http://www.scopus.com/inward/record.url?scp=85007170383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007170383&partnerID=8YFLogxK

U2 - 10.1007/s00198-016-3874-2

DO - 10.1007/s00198-016-3874-2

M3 - Article

SP - 1

EP - 10

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

ER -