Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort

Roxanne E. Jensen, Carol M. Moinpour, Arnold L. Potosky, Tania Lobo, Elizabeth A. Hahn, Ron D. Hays, David Cella, Ashley Wilder Smith, Xiao Cheng Wu, Theresa H Keegan, Lisa E. Paddock, Antoinette M. Stroup, David T. Eton

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The Patient-Reported Outcomes Measurement Information System (PROMIS) was a National Institutes of Health-funded initiative to develop measures of symptoms and function. Responsiveness is the degree to which a measure can detect underlying changes over time. The objective of the current study was to document the responsiveness of 8 PROMIS measures in a large, population-based cancer cohort. METHODS: The Measuring Your Health study recruited 2968 patients who were diagnosed with 1 of 7 cancers between 2010 and 2012 through 4 Surveillance, Epidemiology, and End Results registries. Participants completed a baseline survey (6-13 months after diagnosis) and a 6-month follow-up survey. Changes in 8 PROMIS scores were compared with global ratings of transition, changes in performance status, and clinical events. RESULTS: Measures were responsive to 6-month declines and improvements in performance status with small to large effect sizes (ES) (Cohen d = 0.34-0.71; P <.01). Mean changes and effect sizes were larger for participants who reported declines compared with those who reported improvements. Small-to-medium ES were observed in patients who reported being “a little” worse (d = 0.31-0.56), and medium-to-large ES were observed in those who reported being “a lot” worse (d = 0.53-0.72). Hospitalized participants reported significant score increases, resulting in worsening of pain (d = 0.51), fatigue (d = 0.35), and depression (d = 0.57; all P <.01). Cancer recurrence and progression were associated with smaller increases in pain, fatigue, and sleep disturbance (d = 0.22-0.27). CONCLUSIONS: The current results indicated that all 8 PROMIS measures were sensitive to patient-perceived worsening and improvement and to major clinical events. These findings will be able to inform the design and interpretation of future research studies and clinical initiatives administering PROMIS measures. Cancer 2017;123:327–335.

Original languageEnglish (US)
Pages (from-to)327-335
Number of pages9
JournalCancer
Volume123
Issue number2
DOIs
StatePublished - Jan 1 2017

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Information Systems
Cohort Studies
Neoplasms
Fatigue
Pain
National Institutes of Health (U.S.)
Registries
Sleep
Epidemiology
Patient Reported Outcome Measures
Depression
Recurrence
Health
Population
Surveys and Questionnaires

Keywords

  • oncology
  • patient-reported outcomes
  • responsiveness
  • validation studies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jensen, R. E., Moinpour, C. M., Potosky, A. L., Lobo, T., Hahn, E. A., Hays, R. D., ... Eton, D. T. (2017). Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort. Cancer, 123(2), 327-335. https://doi.org/10.1002/cncr.30354

Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort. / Jensen, Roxanne E.; Moinpour, Carol M.; Potosky, Arnold L.; Lobo, Tania; Hahn, Elizabeth A.; Hays, Ron D.; Cella, David; Smith, Ashley Wilder; Wu, Xiao Cheng; Keegan, Theresa H; Paddock, Lisa E.; Stroup, Antoinette M.; Eton, David T.

In: Cancer, Vol. 123, No. 2, 01.01.2017, p. 327-335.

Research output: Contribution to journalArticle

Jensen, RE, Moinpour, CM, Potosky, AL, Lobo, T, Hahn, EA, Hays, RD, Cella, D, Smith, AW, Wu, XC, Keegan, TH, Paddock, LE, Stroup, AM & Eton, DT 2017, 'Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort', Cancer, vol. 123, no. 2, pp. 327-335. https://doi.org/10.1002/cncr.30354
Jensen, Roxanne E. ; Moinpour, Carol M. ; Potosky, Arnold L. ; Lobo, Tania ; Hahn, Elizabeth A. ; Hays, Ron D. ; Cella, David ; Smith, Ashley Wilder ; Wu, Xiao Cheng ; Keegan, Theresa H ; Paddock, Lisa E. ; Stroup, Antoinette M. ; Eton, David T. / Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort. In: Cancer. 2017 ; Vol. 123, No. 2. pp. 327-335.
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abstract = "BACKGROUND: The Patient-Reported Outcomes Measurement Information System (PROMIS) was a National Institutes of Health-funded initiative to develop measures of symptoms and function. Responsiveness is the degree to which a measure can detect underlying changes over time. The objective of the current study was to document the responsiveness of 8 PROMIS measures in a large, population-based cancer cohort. METHODS: The Measuring Your Health study recruited 2968 patients who were diagnosed with 1 of 7 cancers between 2010 and 2012 through 4 Surveillance, Epidemiology, and End Results registries. Participants completed a baseline survey (6-13 months after diagnosis) and a 6-month follow-up survey. Changes in 8 PROMIS scores were compared with global ratings of transition, changes in performance status, and clinical events. RESULTS: Measures were responsive to 6-month declines and improvements in performance status with small to large effect sizes (ES) (Cohen d = 0.34-0.71; P <.01). Mean changes and effect sizes were larger for participants who reported declines compared with those who reported improvements. Small-to-medium ES were observed in patients who reported being “a little” worse (d = 0.31-0.56), and medium-to-large ES were observed in those who reported being “a lot” worse (d = 0.53-0.72). Hospitalized participants reported significant score increases, resulting in worsening of pain (d = 0.51), fatigue (d = 0.35), and depression (d = 0.57; all P <.01). Cancer recurrence and progression were associated with smaller increases in pain, fatigue, and sleep disturbance (d = 0.22-0.27). CONCLUSIONS: The current results indicated that all 8 PROMIS measures were sensitive to patient-perceived worsening and improvement and to major clinical events. These findings will be able to inform the design and interpretation of future research studies and clinical initiatives administering PROMIS measures. Cancer 2017;123:327–335.",
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AU - Lobo, Tania

AU - Hahn, Elizabeth A.

AU - Hays, Ron D.

AU - Cella, David

AU - Smith, Ashley Wilder

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N2 - BACKGROUND: The Patient-Reported Outcomes Measurement Information System (PROMIS) was a National Institutes of Health-funded initiative to develop measures of symptoms and function. Responsiveness is the degree to which a measure can detect underlying changes over time. The objective of the current study was to document the responsiveness of 8 PROMIS measures in a large, population-based cancer cohort. METHODS: The Measuring Your Health study recruited 2968 patients who were diagnosed with 1 of 7 cancers between 2010 and 2012 through 4 Surveillance, Epidemiology, and End Results registries. Participants completed a baseline survey (6-13 months after diagnosis) and a 6-month follow-up survey. Changes in 8 PROMIS scores were compared with global ratings of transition, changes in performance status, and clinical events. RESULTS: Measures were responsive to 6-month declines and improvements in performance status with small to large effect sizes (ES) (Cohen d = 0.34-0.71; P <.01). Mean changes and effect sizes were larger for participants who reported declines compared with those who reported improvements. Small-to-medium ES were observed in patients who reported being “a little” worse (d = 0.31-0.56), and medium-to-large ES were observed in those who reported being “a lot” worse (d = 0.53-0.72). Hospitalized participants reported significant score increases, resulting in worsening of pain (d = 0.51), fatigue (d = 0.35), and depression (d = 0.57; all P <.01). Cancer recurrence and progression were associated with smaller increases in pain, fatigue, and sleep disturbance (d = 0.22-0.27). CONCLUSIONS: The current results indicated that all 8 PROMIS measures were sensitive to patient-perceived worsening and improvement and to major clinical events. These findings will be able to inform the design and interpretation of future research studies and clinical initiatives administering PROMIS measures. Cancer 2017;123:327–335.

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