Responses of solitary retinal horizontal cells to l-glutamate and kainic acid are antagonized by d-aspartate

Andrew Ishida

doi:10.1016/0006-8993(84)91143-0

Responses of solitary retinal horizontal cells to l-glutamate and kainic acid are antagonized by d-aspartate

Andrew Ishida

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.

Original language	English (US)
Pages (from-to)	25-32
Number of pages	8
Journal	Brain Research
Volume	298
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)91143-0
State	Published - Apr 23 1984
Externally published	Yes

Keywords

d-aspartate
horizontal cell
kainic acid
l-glutamate
l-glutamate antagonists
retina

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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title = "Responses of solitary retinal horizontal cells to l-glutamate and kainic acid are antagonized by d-aspartate",

abstract = "Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.",

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AU - Ishida, Andrew

PY - 1984/4/23

Y1 - 1984/4/23

N2 - Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.

AB - Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.

KW - d-aspartate

KW - horizontal cell

KW - kainic acid

KW - l-glutamate

KW - l-glutamate antagonists

KW - retina

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JF - Brain Research

SN - 0006-8993

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ER -

Responses of solitary retinal horizontal cells to l-glutamate and kainic acid are antagonized by d-aspartate

Abstract

Keywords

ASJC Scopus subject areas

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