Abstract
Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-32 |
| Number of pages | 8 |
| Journal | Brain Research |
| Volume | 298 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 23 1984 |
| Externally published | Yes |
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Keywords
- d-aspartate
- horizontal cell
- kainic acid
- l-glutamate
- l-glutamate antagonists
- retina
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Responses of solitary retinal horizontal cells to l-glutamate and kainic acid are antagonized by d-aspartate. / Ishida, Andrew.
In: Brain Research, Vol. 298, No. 1, 23.04.1984, p. 25-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Responses of solitary retinal horizontal cells to l-glutamate and kainic acid are antagonized by d-aspartate
AU - Ishida, Andrew
PY - 1984/4/23
Y1 - 1984/4/23
N2 - Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.
AB - Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either l-glutamate or kainic acid. The responses to both of these agonists were antagonized by d-aspartate, and unaffected by l-aspartate, l-glutamic acid diethyl ester and folic acid. The results of the present study thus suggest that l-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.
KW - d-aspartate
KW - horizontal cell
KW - kainic acid
KW - l-glutamate
KW - l-glutamate antagonists
KW - retina
UR - http://www.scopus.com/inward/record.url?scp=0021239768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021239768&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(84)91143-0
DO - 10.1016/0006-8993(84)91143-0
M3 - Article
C2 - 6144359
AN - SCOPUS:0021239768
VL - 298
SP - 25
EP - 32
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -