Response to alternative antidepressants in imipramine nonresponders with bulimia nervosa

J. E. Mitchell, R. L. Pyle, E. D. Eckert, D. Hatsukami, Claire Pomeroy, R. Zimmerman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The authors report the results of open-label antidepressant trials in a series of normal weight bulimic women who showed an inadequate response to an initial trial of imipramine hydrochloride as part of a treatment comparison study. The results indicate that a significant percentage of subjects responded to a second trial of an alternative agent. Overall, 47% had a complete remission of symptoms during the second trial, usually with a monoamine oxidase inhibitor or fluoxetine. The authors stress the importance of persisting in trials of alternative agents if bulimic patients fail to respond to an initial trial.

Original languageEnglish (US)
Pages (from-to)291-293
Number of pages3
JournalJournal of Clinical Psychopharmacology
Issue number4
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)


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