Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy

F. Avraham Dilmanian, Terry M. Button, Géraldine Le Duc, Nan Zhong, Louis A. Peña, Jennifer A L Smith, Steve R. Martinez, Tigran Bacarian, Jennifer Tammam, Baorui Ren, Peter M. Farmer, John Kalef-Ezra, Peggy L. Micca, Marta M. Nawrocky, James A. Niederer, F. Peter Recksiek, Alexander Fuchs, Eliot M. Rosen

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Radiotherapeutic doses for malignant gliomas are generally palliative because greater, supposedly curative doses would impart clinically unacceptable damage to nearby vital CNS tissues. To improve radiation treatment for human gliomas, we evaluated microbeam radiation therapy, which utilizes an array of parallel, microscopically thin (<100 μm) planar beams (microbeams) of synchrotron-generated X rays. Rats with i.c. 9L gliosarcoma tumors were exposed laterally to a single microbeam, 27 μm wide and 3.8 mm high, stepwise, to produce irradiation arrays with 50, 75, or 100 μm of on-center beam spacings and 150, 250, 300, or 500 Gy of in-slice, skin-entrance, single-exposure doses. The resulting array size was 9 mm wide and 10.4 mm high (using three 3.8-mm vertical tiers); the beam's median energy was ∼ 70 keV. When all data were collated, the median survival was 70 days; no depletion of nerve cells was observed. However, when data from the highest skin-entrance dose and/or the smallest microbeam spacings were excluded, the median survival time of the subset of rats was 170 days, and no white matter necrosis was observed. Others have reported unilateral single-exposure broad-beam irradiation of i.c. 9L gliosarcomas at 22.5 Gy with a median survival of only ∼34 days and with severe depletion of neurons. These results suggest that the therapeutic index of unidirectional microbeams is larger than that of the broad beams and that an application for microbeam radiation therapy in treating certain malignant brain tumors may be found in the future.

Original languageEnglish (US)
Pages (from-to)26-38
Number of pages13
JournalNeuro-Oncology
Volume4
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Gliosarcoma
Radiotherapy
Glioma
Survival
Neurons
Skin
Synchrotrons
Brain Neoplasms
Necrosis
X-Rays
Radiation
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Dilmanian, F. A., Button, T. M., Le Duc, G., Zhong, N., Peña, L. A., Smith, J. A. L., ... Rosen, E. M. (2002). Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. Neuro-Oncology, 4(1), 26-38. https://doi.org/10.1215/Sq522851701000412

Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. / Dilmanian, F. Avraham; Button, Terry M.; Le Duc, Géraldine; Zhong, Nan; Peña, Louis A.; Smith, Jennifer A L; Martinez, Steve R.; Bacarian, Tigran; Tammam, Jennifer; Ren, Baorui; Farmer, Peter M.; Kalef-Ezra, John; Micca, Peggy L.; Nawrocky, Marta M.; Niederer, James A.; Recksiek, F. Peter; Fuchs, Alexander; Rosen, Eliot M.

In: Neuro-Oncology, Vol. 4, No. 1, 2002, p. 26-38.

Research output: Contribution to journalArticle

Dilmanian, FA, Button, TM, Le Duc, G, Zhong, N, Peña, LA, Smith, JAL, Martinez, SR, Bacarian, T, Tammam, J, Ren, B, Farmer, PM, Kalef-Ezra, J, Micca, PL, Nawrocky, MM, Niederer, JA, Recksiek, FP, Fuchs, A & Rosen, EM 2002, 'Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy', Neuro-Oncology, vol. 4, no. 1, pp. 26-38. https://doi.org/10.1215/Sq522851701000412
Dilmanian FA, Button TM, Le Duc G, Zhong N, Peña LA, Smith JAL et al. Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. Neuro-Oncology. 2002;4(1):26-38. https://doi.org/10.1215/Sq522851701000412
Dilmanian, F. Avraham ; Button, Terry M. ; Le Duc, Géraldine ; Zhong, Nan ; Peña, Louis A. ; Smith, Jennifer A L ; Martinez, Steve R. ; Bacarian, Tigran ; Tammam, Jennifer ; Ren, Baorui ; Farmer, Peter M. ; Kalef-Ezra, John ; Micca, Peggy L. ; Nawrocky, Marta M. ; Niederer, James A. ; Recksiek, F. Peter ; Fuchs, Alexander ; Rosen, Eliot M. / Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. In: Neuro-Oncology. 2002 ; Vol. 4, No. 1. pp. 26-38.
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AU - Dilmanian, F. Avraham

AU - Button, Terry M.

AU - Le Duc, Géraldine

AU - Zhong, Nan

AU - Peña, Louis A.

AU - Smith, Jennifer A L

AU - Martinez, Steve R.

AU - Bacarian, Tigran

AU - Tammam, Jennifer

AU - Ren, Baorui

AU - Farmer, Peter M.

AU - Kalef-Ezra, John

AU - Micca, Peggy L.

AU - Nawrocky, Marta M.

AU - Niederer, James A.

AU - Recksiek, F. Peter

AU - Fuchs, Alexander

AU - Rosen, Eliot M.

PY - 2002

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