Abstract
Plasma corticoid levels and changes in adrenocortical morphology were studied in fetal and neonatal lambs infected with one of 3 agents capable of causing congenital infection. The agents, Brucella ovis, Border disease, and/or rubella vaccine virus, were introduced by intrafetal inoculations at different stages of fetal development. Heparinized blood was collected from fetal and neonatal lambs and their ewes prior to the time they were killed, and adrenals were then saved for histologic evaluation. Values obtained from infected lambs were compared to those of heparinized samples collected daily for 3 weeks prior to birth via a catheter from 3 control lambs. Precocious adrenocortical activity measured by both morphologic and physiologic parameters was observed in lambs infected with these agents after 130 days of the 148 day gestation period. In 2 instances, the increased adrenocortical activity was associated with premature delivery. Congenital infection with these 3 agents appears to result in fetal stress.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 622-627 |
| Number of pages | 6 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 114 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 1 1972 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Response of fetal adrenal cortex to congenital infections. / Osburn, Bennie; Drost, M.; Stabenfeldt, G. H.
In: American Journal of Obstetrics and Gynecology, Vol. 114, No. 5, 01.11.1972, p. 622-627.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response of fetal adrenal cortex to congenital infections
AU - Osburn, Bennie
AU - Drost, M.
AU - Stabenfeldt, G. H.
PY - 1972/11/1
Y1 - 1972/11/1
N2 - Plasma corticoid levels and changes in adrenocortical morphology were studied in fetal and neonatal lambs infected with one of 3 agents capable of causing congenital infection. The agents, Brucella ovis, Border disease, and/or rubella vaccine virus, were introduced by intrafetal inoculations at different stages of fetal development. Heparinized blood was collected from fetal and neonatal lambs and their ewes prior to the time they were killed, and adrenals were then saved for histologic evaluation. Values obtained from infected lambs were compared to those of heparinized samples collected daily for 3 weeks prior to birth via a catheter from 3 control lambs. Precocious adrenocortical activity measured by both morphologic and physiologic parameters was observed in lambs infected with these agents after 130 days of the 148 day gestation period. In 2 instances, the increased adrenocortical activity was associated with premature delivery. Congenital infection with these 3 agents appears to result in fetal stress.
AB - Plasma corticoid levels and changes in adrenocortical morphology were studied in fetal and neonatal lambs infected with one of 3 agents capable of causing congenital infection. The agents, Brucella ovis, Border disease, and/or rubella vaccine virus, were introduced by intrafetal inoculations at different stages of fetal development. Heparinized blood was collected from fetal and neonatal lambs and their ewes prior to the time they were killed, and adrenals were then saved for histologic evaluation. Values obtained from infected lambs were compared to those of heparinized samples collected daily for 3 weeks prior to birth via a catheter from 3 control lambs. Precocious adrenocortical activity measured by both morphologic and physiologic parameters was observed in lambs infected with these agents after 130 days of the 148 day gestation period. In 2 instances, the increased adrenocortical activity was associated with premature delivery. Congenital infection with these 3 agents appears to result in fetal stress.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015421394&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(72)90839-3
DO - 10.1016/0002-9378(72)90839-3
M3 - Article
C2 - 4673970
AN - SCOPUS:0015421394
VL - 114
SP - 622
EP - 627
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 5
ER -