Response of dogs with functional pituitary macroadenomas and macrocarcinomas to radiation

S. W. Dow, Richard A Lecouteur, R. A W Rosychuk, B. E. Powers, R. J. Kemppainen, E. L. Gillette

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A prospective study was conducted to assess the use of radiation therapy for treatment of dogs with large, functional pituitary tumours and pituitary‐dependent hyperadrenocorticism. Four dogs received only pituitary irradiation, whereas two dogs received irradiation and concurrent mitotane treatment. Effects of radiation therapy on tumour size and function were assessed by sequential CT scans, ACTH assays and ACTH stimulation tests. Reduction in tumour size and resolution of neurological abnormalities occurred in all dogs. The mean and median survival time following irradiation for dogs in this report was 740 days and 743 days, respectively. Atnecropsy, a pituitary chromophobe adenoma was detected in three dogs, and a pituitary carcinoma in one dog; necropsy was not carried out on two dogs. Pituitary hypersecretion of ACTH persisted for at

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalJournal of Small Animal Practice
Volume31
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

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Dogs
Radiation
dogs
Pituitary Neoplasms
irradiation
radiotherapy
Adrenocorticotropic Hormone
neoplasms
Pituitary Irradiation
Radiotherapy
Chromophobe Adenoma
mitotane
Mitotane
Adrenocortical Hyperfunction
hypersecretion
Pituitary ACTH Hypersecretion
hyperadrenocorticism
adenoma
prospective studies
computed tomography

ASJC Scopus subject areas

  • Small Animals

Cite this

Response of dogs with functional pituitary macroadenomas and macrocarcinomas to radiation. / Dow, S. W.; Lecouteur, Richard A; Rosychuk, R. A W; Powers, B. E.; Kemppainen, R. J.; Gillette, E. L.

In: Journal of Small Animal Practice, Vol. 31, No. 6, 1990, p. 287-294.

Research output: Contribution to journalArticle

Dow, S. W. ; Lecouteur, Richard A ; Rosychuk, R. A W ; Powers, B. E. ; Kemppainen, R. J. ; Gillette, E. L. / Response of dogs with functional pituitary macroadenomas and macrocarcinomas to radiation. In: Journal of Small Animal Practice. 1990 ; Vol. 31, No. 6. pp. 287-294.
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