Abstract
Immunized and nonimmunized B-lymphocyte-deficient CBD2/F1 (CBA/N x DBA/2) mice were infected with Nocardia asteroides GUH-2 by different routes of inoculation. The 50% lethal dose, organ clearance, footpad response, and antibody titers were measured. It was observed that B-cell-deficient male mice were not significantly more susceptible to infection than normal female controls even though the female CBD2/F1 mice produced antinocardial antibodies while the deficient male animals did not. Preimmunized male and female mice were identical in their ability to clear N. asteroides from the adrenals, brain, kidneys, liver, lungs, and spleen. Both DBA/2 and CBD2/F1 female mice were more susceptible than their male littermates to intravenous challenge with N. asteroides GUH-2. This enhanced susceptibility of the female mice as compared to the male littermates appeared to be due to a decreased resistance to nocardial infections in the brains of the female animals. These data indicate that antibody and certain B-lymphocyte subpopulations are not essential components in host resistance to N. asteroides GUH-2 in these mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | Infection and Immunity |
| Volume | 35 |
| Issue number | 1 |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Immunology
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Response of CBA/N x DBA2/F1 mice to Nocardia asteroides. / Beaman, B. L.; Gershwin, M. Eric; Ahmed, A.; Scates, S. M.; Deem, R.
In: Infection and Immunity, Vol. 35, No. 1, 1982, p. 111-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Response of CBA/N x DBA2/F1 mice to Nocardia asteroides
AU - Beaman, B. L.
AU - Gershwin, M. Eric
AU - Ahmed, A.
AU - Scates, S. M.
AU - Deem, R.
PY - 1982
Y1 - 1982
N2 - Immunized and nonimmunized B-lymphocyte-deficient CBD2/F1 (CBA/N x DBA/2) mice were infected with Nocardia asteroides GUH-2 by different routes of inoculation. The 50% lethal dose, organ clearance, footpad response, and antibody titers were measured. It was observed that B-cell-deficient male mice were not significantly more susceptible to infection than normal female controls even though the female CBD2/F1 mice produced antinocardial antibodies while the deficient male animals did not. Preimmunized male and female mice were identical in their ability to clear N. asteroides from the adrenals, brain, kidneys, liver, lungs, and spleen. Both DBA/2 and CBD2/F1 female mice were more susceptible than their male littermates to intravenous challenge with N. asteroides GUH-2. This enhanced susceptibility of the female mice as compared to the male littermates appeared to be due to a decreased resistance to nocardial infections in the brains of the female animals. These data indicate that antibody and certain B-lymphocyte subpopulations are not essential components in host resistance to N. asteroides GUH-2 in these mice.
AB - Immunized and nonimmunized B-lymphocyte-deficient CBD2/F1 (CBA/N x DBA/2) mice were infected with Nocardia asteroides GUH-2 by different routes of inoculation. The 50% lethal dose, organ clearance, footpad response, and antibody titers were measured. It was observed that B-cell-deficient male mice were not significantly more susceptible to infection than normal female controls even though the female CBD2/F1 mice produced antinocardial antibodies while the deficient male animals did not. Preimmunized male and female mice were identical in their ability to clear N. asteroides from the adrenals, brain, kidneys, liver, lungs, and spleen. Both DBA/2 and CBD2/F1 female mice were more susceptible than their male littermates to intravenous challenge with N. asteroides GUH-2. This enhanced susceptibility of the female mice as compared to the male littermates appeared to be due to a decreased resistance to nocardial infections in the brains of the female animals. These data indicate that antibody and certain B-lymphocyte subpopulations are not essential components in host resistance to N. asteroides GUH-2 in these mice.
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M3 - Article
C2 - 7033133
AN - SCOPUS:0020062386
VL - 35
SP - 111
EP - 116
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 1
ER -