Respiratory cancer and other chronic disease mortality among silicotics in California

D. F. Goldsmith, J. J. Beaumont, L. A. Morrin, Marc B Schenker

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Silicotics have increased mortality from tuberculosis (TB) and from nonmalignant respiratory diseases (NMRD), including silicosis and silicotuberculosis. Since the publication of the International Agency for Research on Cancer monograph in 1987 indicating that silica was a probable human carcinogen, there has been an extensive debate about the cancer risks among silicotics. The authors identified 590 claims for silicosis among a registry of lung diseases compiled from California Workers' Compensation cases from 1945 to 1975. Using state vital records, we determined the mortality risks from 1946 to 1991. Our findings confirmed that these claimants had a significantly elevated risk for all causes of death with a standardized mortality ratio (SMR) of 1.30 (95% confidence interval [CI] = 1.18, 1.43); TB had a SMR of 56.35 (95% CI = 41.10, 75.40) and NMRD a SMR of 3.80 (95% CI = 3.11, 4.60). Cancers of the trachea, bronchus, and lung had a SMR of 1.90 (95% CI = 1.35, 2.60). For malignancies of the large intestine, there was a previously unreported SMR of 2.08 (95% CI = 1.14, 3.50). Mortality from all diseases of the heart was significantly less than expected with a SMR of 0.68 (95% CI = 0.55, 0.83); cancers of the prostate and lymphatic system were also significantly low with SMRs of 0.26 (95% CI = 0.03, 0.94) and 0.17 (95% CI = 0.04, 0.97), respectively. Workers with silicosis should be warned about these chronic disease risks, and prevention efforts to control occupational silica dust exposure should become a higher priority.

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalAmerican Journal of Industrial Medicine
Volume28
Issue number4
StatePublished - 1995

Fingerprint

Chronic Disease
Confidence Intervals
Mortality
Silicosis
Neoplasms
Silicon Dioxide
Silicotuberculosis
Tuberculosis
International Agencies
Workers' Compensation
Lymphatic System
Large Intestine
Bronchi
Trachea
Dust
Carcinogens
Lung Diseases
Registries
Publications
Cause of Death

Keywords

  • cancer of the large intestine
  • nonmalignant respiratory disease
  • prevention
  • pulmonary cancer
  • silicotics
  • tuberculosis
  • Workers' Compensation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Respiratory cancer and other chronic disease mortality among silicotics in California. / Goldsmith, D. F.; Beaumont, J. J.; Morrin, L. A.; Schenker, Marc B.

In: American Journal of Industrial Medicine, Vol. 28, No. 4, 1995, p. 459-467.

Research output: Contribution to journalArticle

Goldsmith, D. F. ; Beaumont, J. J. ; Morrin, L. A. ; Schenker, Marc B. / Respiratory cancer and other chronic disease mortality among silicotics in California. In: American Journal of Industrial Medicine. 1995 ; Vol. 28, No. 4. pp. 459-467.
@article{6ff53db6e8bb4ee19899b80e9c17f603,
title = "Respiratory cancer and other chronic disease mortality among silicotics in California",
abstract = "Silicotics have increased mortality from tuberculosis (TB) and from nonmalignant respiratory diseases (NMRD), including silicosis and silicotuberculosis. Since the publication of the International Agency for Research on Cancer monograph in 1987 indicating that silica was a probable human carcinogen, there has been an extensive debate about the cancer risks among silicotics. The authors identified 590 claims for silicosis among a registry of lung diseases compiled from California Workers' Compensation cases from 1945 to 1975. Using state vital records, we determined the mortality risks from 1946 to 1991. Our findings confirmed that these claimants had a significantly elevated risk for all causes of death with a standardized mortality ratio (SMR) of 1.30 (95{\%} confidence interval [CI] = 1.18, 1.43); TB had a SMR of 56.35 (95{\%} CI = 41.10, 75.40) and NMRD a SMR of 3.80 (95{\%} CI = 3.11, 4.60). Cancers of the trachea, bronchus, and lung had a SMR of 1.90 (95{\%} CI = 1.35, 2.60). For malignancies of the large intestine, there was a previously unreported SMR of 2.08 (95{\%} CI = 1.14, 3.50). Mortality from all diseases of the heart was significantly less than expected with a SMR of 0.68 (95{\%} CI = 0.55, 0.83); cancers of the prostate and lymphatic system were also significantly low with SMRs of 0.26 (95{\%} CI = 0.03, 0.94) and 0.17 (95{\%} CI = 0.04, 0.97), respectively. Workers with silicosis should be warned about these chronic disease risks, and prevention efforts to control occupational silica dust exposure should become a higher priority.",
keywords = "cancer of the large intestine, nonmalignant respiratory disease, prevention, pulmonary cancer, silicotics, tuberculosis, Workers' Compensation",
author = "Goldsmith, {D. F.} and Beaumont, {J. J.} and Morrin, {L. A.} and Schenker, {Marc B}",
year = "1995",
language = "English (US)",
volume = "28",
pages = "459--467",
journal = "American Journal of Industrial Medicine",
issn = "0271-3586",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Respiratory cancer and other chronic disease mortality among silicotics in California

AU - Goldsmith, D. F.

AU - Beaumont, J. J.

AU - Morrin, L. A.

AU - Schenker, Marc B

PY - 1995

Y1 - 1995

N2 - Silicotics have increased mortality from tuberculosis (TB) and from nonmalignant respiratory diseases (NMRD), including silicosis and silicotuberculosis. Since the publication of the International Agency for Research on Cancer monograph in 1987 indicating that silica was a probable human carcinogen, there has been an extensive debate about the cancer risks among silicotics. The authors identified 590 claims for silicosis among a registry of lung diseases compiled from California Workers' Compensation cases from 1945 to 1975. Using state vital records, we determined the mortality risks from 1946 to 1991. Our findings confirmed that these claimants had a significantly elevated risk for all causes of death with a standardized mortality ratio (SMR) of 1.30 (95% confidence interval [CI] = 1.18, 1.43); TB had a SMR of 56.35 (95% CI = 41.10, 75.40) and NMRD a SMR of 3.80 (95% CI = 3.11, 4.60). Cancers of the trachea, bronchus, and lung had a SMR of 1.90 (95% CI = 1.35, 2.60). For malignancies of the large intestine, there was a previously unreported SMR of 2.08 (95% CI = 1.14, 3.50). Mortality from all diseases of the heart was significantly less than expected with a SMR of 0.68 (95% CI = 0.55, 0.83); cancers of the prostate and lymphatic system were also significantly low with SMRs of 0.26 (95% CI = 0.03, 0.94) and 0.17 (95% CI = 0.04, 0.97), respectively. Workers with silicosis should be warned about these chronic disease risks, and prevention efforts to control occupational silica dust exposure should become a higher priority.

AB - Silicotics have increased mortality from tuberculosis (TB) and from nonmalignant respiratory diseases (NMRD), including silicosis and silicotuberculosis. Since the publication of the International Agency for Research on Cancer monograph in 1987 indicating that silica was a probable human carcinogen, there has been an extensive debate about the cancer risks among silicotics. The authors identified 590 claims for silicosis among a registry of lung diseases compiled from California Workers' Compensation cases from 1945 to 1975. Using state vital records, we determined the mortality risks from 1946 to 1991. Our findings confirmed that these claimants had a significantly elevated risk for all causes of death with a standardized mortality ratio (SMR) of 1.30 (95% confidence interval [CI] = 1.18, 1.43); TB had a SMR of 56.35 (95% CI = 41.10, 75.40) and NMRD a SMR of 3.80 (95% CI = 3.11, 4.60). Cancers of the trachea, bronchus, and lung had a SMR of 1.90 (95% CI = 1.35, 2.60). For malignancies of the large intestine, there was a previously unreported SMR of 2.08 (95% CI = 1.14, 3.50). Mortality from all diseases of the heart was significantly less than expected with a SMR of 0.68 (95% CI = 0.55, 0.83); cancers of the prostate and lymphatic system were also significantly low with SMRs of 0.26 (95% CI = 0.03, 0.94) and 0.17 (95% CI = 0.04, 0.97), respectively. Workers with silicosis should be warned about these chronic disease risks, and prevention efforts to control occupational silica dust exposure should become a higher priority.

KW - cancer of the large intestine

KW - nonmalignant respiratory disease

KW - prevention

KW - pulmonary cancer

KW - silicotics

KW - tuberculosis

KW - Workers' Compensation

UR - http://www.scopus.com/inward/record.url?scp=0029151116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029151116&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 459

EP - 467

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

SN - 0271-3586

IS - 4

ER -