Resistance to Transformation by Insertionally Activated c-erbB Is a Dominant Phenotype in Fibroblasts

T. H. Carter, N. Dominguez, L. Zeng, Hsing-Jien Kung

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Tissue-specific factors influence whether cells are susceptible to transformation by erbB oncogenes. Avian fibroblasts resist transformation by insertionally activated c-erbB (IAc-erbB), whereas erythroblasts are transformed by this mutant of the epidermal growth factor receptor. In studies presented here, NIH/3T3 cells resisted transformation by IAc-erbB. This finding indicates that the nonpermissiveness of fibroblasts is conserved between avian and murine species. Surprisingly, expression of IAc-erbB blocked transformation by a v-erbB allele. The trans-dominant interference by IAc-erbB occurred despite expression at levels lower than for v-erbB. Together with previous reports, the results indicate that IAc-erbB can exert opposite growth effects in different tissues. The switch from positive to negative growth regulation, which depends on the cellular context, provides novel insight into tissue-specific regulation of receptor tyrosine kinases. Evasion of cell-specific inhibition apparently contributes to the distinct tissue tropisms of various erbB mutants.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalVirology
Volume212
Issue number1
DOIs
StatePublished - Sep 10 1995
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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