Resistance of colostrum-deprived domestic lambs to infection with deer adenovirus

Jennifer K. Imus, Howard D. Lehmkuhl, Leslie Woods

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Seven colostrum-deprived, 3–4-wk-old Rambouillet–Hampshire lambs were inoculated via the mucous membranes with deer adenovirus (DAdV) and monitored for clinical signs for 21 d post-inoculation at which time animals were euthanized and postmortem examinations were performed. Pre-inoculation and post-inoculation serum samples were tested for antibodies to DAdV, ovine adenovirus 7, bovine adenovirus 7, and goat adenovirus 1. Evidence for DAdV infection was determined by virus isolation, PCR tests, and histopathology with immunohistochemistry tests for DAdV. No clinical signs or lesions consistent with adenoviral hemorrhagic disease (AHD) in deer were seen in the lambs, and the lambs did not seroconvert to DAdV. DAdV was not detected by PCR, virus isolation, or immunohistochemistry in any of the samples tested from the lambs. A positive control deer similarly inoculated with DAdV developed fatal AHD 1 wk post-inoculation. Our colostrum-deprived lambs did not become infected when inoculated with DAdV.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Issue number1
StatePublished - Jan 1 2019
Externally publishedYes


  • Deer adenovirus
  • Deer atadenovirus A experimental infection
  • sheep

ASJC Scopus subject areas

  • veterinary(all)


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