Residual public repertoires to self

Stephen S. Wilson, Peter Van Den Elzen, Emanual Michael Maverakis, Jonathan T. Beech, Todd A. Braciak, Vipin Kumar, Eli E. Sercarz

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The consensus view about the constitution of the T cell receptor repertoire has shifted greatly even during this decade. Although the discovery of autoimmunity in the fifties had clearly shown that a repertoire must exist directed against self antigens, the extent of this repertoire was not fully appreciated. In our work we have tried to elucidate the nature of the antigenic specificities against which this self-directed repertoire is directed. The non-tolerized (residual) self-directed repertoire is a direct consequence of the hierarchy of antigenic determinant display, and is the most important influence in the organism's choice of which T cells to delete. Certain determinants remain 'silent' and are neither displayed in the thymus nor in the periphery: these are a heterogeneous group which are invisible to T cells for a variety of reasons. One reason relates to the processing and presentation of determinants, and a second derives from the nature of the T cell receptor (TcR) and the avidity of the T cell for its target specificity. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalJournal of Neuroimmunology
Volume107
Issue number2
DOIs
StatePublished - Jul 24 2000

Keywords

  • Anergy
  • Deletion
  • EAE
  • Neonatal tolerance
  • T cell repertoire
  • T(H)1
  • T(H)2

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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    Wilson, S. S., Van Den Elzen, P., Maverakis, E. M., Beech, J. T., Braciak, T. A., Kumar, V., & Sercarz, E. E. (2000). Residual public repertoires to self. Journal of Neuroimmunology, 107(2), 233-239. https://doi.org/10.1016/S0165-5728(00)00218-6