Residential proximity to traffic and female pubertal development

Laura A. McGuinn, Robert W. Voss, Cecile A. Laurent, Louise C. Greenspan, Lawrence H. Kushi, Gayle C. Windham

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background Traffic-related air pollution (TRAP) has been linked with several adverse health outcomes, including preterm birth and low birth weight, which are both related to onset of puberty. No studies to date have investigated the association between TRAP and altered pubertal timing. Objective Determine the association between residential proximity to traffic, as a marker of long-term TRAP exposure, and age at pubertal onset in a longitudinal study of girls. Methods We analyzed data for 437 girls at the CYGNET study site of the Breast Cancer and Environment Research Program. TRAP exposure was assessed using several measures of residential proximity to traffic based on address at study entry. Using accelerated failure time models, we calculated time ratios (TRs) and their corresponding 95% confidence intervals (CIs) for specified traffic metrics and pubertal onset, defined as stage 2 or higher for breast or pubic hair development (respectively, B2 + and PH2 +). Models were adjusted for race/ethnicity, household income, and cotinine levels. Results At baseline, 71% of girls lived within 150 m of a major road. The median age of onset was 10.3 years for B2 + and 10.9 years for PH2 +. Living within 150 m downwind of a major road was associated with earlier onset of PH2 + (TR 0.96, 95% CI 0.93, 0.99). Girls in the highest quintile of either distance-weighted traffic density, annual average daily traffic, and/or traffic density also reached PH2 + earlier than girls in the lowest quintiles. Conclusions In this first study to assess the association between residential proximity to traffic and pubertal onset we found girls with higher exposure reached one pubertal milestone several months earlier than low exposed girls, even after consideration of likely confounders. Results should be expanded in larger epidemiological studies, and with measured levels of air pollutants.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalEnvironment International
Volume94
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Fingerprint

atmospheric pollution
pollution exposure
confidence interval
traffic
road
household income
ethnicity
hair
research program
cancer

Keywords

  • Breast development
  • Cohort study
  • Puberty
  • Traffic-related air pollution

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

McGuinn, L. A., Voss, R. W., Laurent, C. A., Greenspan, L. C., Kushi, L. H., & Windham, G. C. (2016). Residential proximity to traffic and female pubertal development. Environment International, 94, 635-641. https://doi.org/10.1016/j.envint.2016.06.031

Residential proximity to traffic and female pubertal development. / McGuinn, Laura A.; Voss, Robert W.; Laurent, Cecile A.; Greenspan, Louise C.; Kushi, Lawrence H.; Windham, Gayle C.

In: Environment International, Vol. 94, 01.09.2016, p. 635-641.

Research output: Contribution to journalArticle

McGuinn, LA, Voss, RW, Laurent, CA, Greenspan, LC, Kushi, LH & Windham, GC 2016, 'Residential proximity to traffic and female pubertal development', Environment International, vol. 94, pp. 635-641. https://doi.org/10.1016/j.envint.2016.06.031
McGuinn LA, Voss RW, Laurent CA, Greenspan LC, Kushi LH, Windham GC. Residential proximity to traffic and female pubertal development. Environment International. 2016 Sep 1;94:635-641. https://doi.org/10.1016/j.envint.2016.06.031
McGuinn, Laura A. ; Voss, Robert W. ; Laurent, Cecile A. ; Greenspan, Louise C. ; Kushi, Lawrence H. ; Windham, Gayle C. / Residential proximity to traffic and female pubertal development. In: Environment International. 2016 ; Vol. 94. pp. 635-641.
@article{12f0167c082b4ba0850f5bc9aedcd008,
title = "Residential proximity to traffic and female pubertal development",
abstract = "Background Traffic-related air pollution (TRAP) has been linked with several adverse health outcomes, including preterm birth and low birth weight, which are both related to onset of puberty. No studies to date have investigated the association between TRAP and altered pubertal timing. Objective Determine the association between residential proximity to traffic, as a marker of long-term TRAP exposure, and age at pubertal onset in a longitudinal study of girls. Methods We analyzed data for 437 girls at the CYGNET study site of the Breast Cancer and Environment Research Program. TRAP exposure was assessed using several measures of residential proximity to traffic based on address at study entry. Using accelerated failure time models, we calculated time ratios (TRs) and their corresponding 95{\%} confidence intervals (CIs) for specified traffic metrics and pubertal onset, defined as stage 2 or higher for breast or pubic hair development (respectively, B2 + and PH2 +). Models were adjusted for race/ethnicity, household income, and cotinine levels. Results At baseline, 71{\%} of girls lived within 150 m of a major road. The median age of onset was 10.3 years for B2 + and 10.9 years for PH2 +. Living within 150 m downwind of a major road was associated with earlier onset of PH2 + (TR 0.96, 95{\%} CI 0.93, 0.99). Girls in the highest quintile of either distance-weighted traffic density, annual average daily traffic, and/or traffic density also reached PH2 + earlier than girls in the lowest quintiles. Conclusions In this first study to assess the association between residential proximity to traffic and pubertal onset we found girls with higher exposure reached one pubertal milestone several months earlier than low exposed girls, even after consideration of likely confounders. Results should be expanded in larger epidemiological studies, and with measured levels of air pollutants.",
keywords = "Breast development, Cohort study, Puberty, Traffic-related air pollution",
author = "McGuinn, {Laura A.} and Voss, {Robert W.} and Laurent, {Cecile A.} and Greenspan, {Louise C.} and Kushi, {Lawrence H.} and Windham, {Gayle C.}",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.envint.2016.06.031",
language = "English (US)",
volume = "94",
pages = "635--641",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Residential proximity to traffic and female pubertal development

AU - McGuinn, Laura A.

AU - Voss, Robert W.

AU - Laurent, Cecile A.

AU - Greenspan, Louise C.

AU - Kushi, Lawrence H.

AU - Windham, Gayle C.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background Traffic-related air pollution (TRAP) has been linked with several adverse health outcomes, including preterm birth and low birth weight, which are both related to onset of puberty. No studies to date have investigated the association between TRAP and altered pubertal timing. Objective Determine the association between residential proximity to traffic, as a marker of long-term TRAP exposure, and age at pubertal onset in a longitudinal study of girls. Methods We analyzed data for 437 girls at the CYGNET study site of the Breast Cancer and Environment Research Program. TRAP exposure was assessed using several measures of residential proximity to traffic based on address at study entry. Using accelerated failure time models, we calculated time ratios (TRs) and their corresponding 95% confidence intervals (CIs) for specified traffic metrics and pubertal onset, defined as stage 2 or higher for breast or pubic hair development (respectively, B2 + and PH2 +). Models were adjusted for race/ethnicity, household income, and cotinine levels. Results At baseline, 71% of girls lived within 150 m of a major road. The median age of onset was 10.3 years for B2 + and 10.9 years for PH2 +. Living within 150 m downwind of a major road was associated with earlier onset of PH2 + (TR 0.96, 95% CI 0.93, 0.99). Girls in the highest quintile of either distance-weighted traffic density, annual average daily traffic, and/or traffic density also reached PH2 + earlier than girls in the lowest quintiles. Conclusions In this first study to assess the association between residential proximity to traffic and pubertal onset we found girls with higher exposure reached one pubertal milestone several months earlier than low exposed girls, even after consideration of likely confounders. Results should be expanded in larger epidemiological studies, and with measured levels of air pollutants.

AB - Background Traffic-related air pollution (TRAP) has been linked with several adverse health outcomes, including preterm birth and low birth weight, which are both related to onset of puberty. No studies to date have investigated the association between TRAP and altered pubertal timing. Objective Determine the association between residential proximity to traffic, as a marker of long-term TRAP exposure, and age at pubertal onset in a longitudinal study of girls. Methods We analyzed data for 437 girls at the CYGNET study site of the Breast Cancer and Environment Research Program. TRAP exposure was assessed using several measures of residential proximity to traffic based on address at study entry. Using accelerated failure time models, we calculated time ratios (TRs) and their corresponding 95% confidence intervals (CIs) for specified traffic metrics and pubertal onset, defined as stage 2 or higher for breast or pubic hair development (respectively, B2 + and PH2 +). Models were adjusted for race/ethnicity, household income, and cotinine levels. Results At baseline, 71% of girls lived within 150 m of a major road. The median age of onset was 10.3 years for B2 + and 10.9 years for PH2 +. Living within 150 m downwind of a major road was associated with earlier onset of PH2 + (TR 0.96, 95% CI 0.93, 0.99). Girls in the highest quintile of either distance-weighted traffic density, annual average daily traffic, and/or traffic density also reached PH2 + earlier than girls in the lowest quintiles. Conclusions In this first study to assess the association between residential proximity to traffic and pubertal onset we found girls with higher exposure reached one pubertal milestone several months earlier than low exposed girls, even after consideration of likely confounders. Results should be expanded in larger epidemiological studies, and with measured levels of air pollutants.

KW - Breast development

KW - Cohort study

KW - Puberty

KW - Traffic-related air pollution

UR - http://www.scopus.com/inward/record.url?scp=84989229297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989229297&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2016.06.031

DO - 10.1016/j.envint.2016.06.031

M3 - Article

AN - SCOPUS:84989229297

VL - 94

SP - 635

EP - 641

JO - Environmental International

JF - Environmental International

SN - 0160-4120

ER -