Resection of temporal neocortex during multiple hippocampal transections for mesial temporal lobe epilepsy does not affect seizure or memory outcome

Fady Girgis, Madeline E. Greil, Philip S. Fastenau, Jennifer Sweet, Hans Lüders, Jonathan P. Miller

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: Multiple hippocampal transection (MHT) is a surgical treatment for mesial temporal lobe epilepsy associated with improved postoperative neuropsychological outcomes compared with lobectomy. OBJECTIVE: To determine whether resection of the amygdala and anterior temporal neocortex during MHT affects postoperative seizure/memory outcome. METHODS: Seventeen patients with normal magnetic resonance imaging and stereoelectroencephalogram- proven drug-resistant dominant mesial temporal lobe epilepsy were treated with MHT. Nine patients underwent MHT alone (MHT-) and 8 patients underwent MHT plus removal of the amygdala and anterior 4.5 cm of temporal neocortex lateral to the fusiform gyrus (MHT+). Verbal and visual-spatial memory were assessed in all patients preoperatively and in 14 patients postoperatively using the Wechsler Memory Scale. Postoperative seizure control was assessed at 12 months for all patients. RESULTS: Overall, 11 of 17 patients (64.7%)were Engel class 1 at 1 year (6/9 MHT-, 5/8 MHT+, P = .38), and 10 of 14 patients (71.4%) had no significant postoperative decline in either verbal or visual memory (6/8 MHT-, 4/6 MHT+, P = .42). Verbal memory declined in 2 of 8 MHT- and 1 of 6 MHT+ patients, and visual memory declined in 1 of 8 MHT- and 2 of 6 MHT+ patients. Two patients had improved visual memory postoperatively, both in the MHT+ group. CONCLUSION: MHT on the dominant side is associated with high rates of seizure freedom and favorable memory preservation outcomes regardless of the extent of neocortical resection. Preservation of the temporal neocortex and amygdala during MHT does not appear to decrease the risk of postoperative memory decline, nor does it alter seizure outcome.

Original languageEnglish (US)
Pages (from-to)711-717
Number of pages7
JournalOperative Neurosurgery
Volume13
Issue number6
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Neocortex
Seizures
Amygdala
Wechsler Scales
Temporal Lobe
Magnetic Resonance Imaging

Keywords

  • Epilepsy
  • Memory
  • Multiple hippocampal transections

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Resection of temporal neocortex during multiple hippocampal transections for mesial temporal lobe epilepsy does not affect seizure or memory outcome. / Girgis, Fady; Greil, Madeline E.; Fastenau, Philip S.; Sweet, Jennifer; Lüders, Hans; Miller, Jonathan P.

In: Operative Neurosurgery, Vol. 13, No. 6, 01.12.2017, p. 711-717.

Research output: Contribution to journalArticle

Girgis, Fady ; Greil, Madeline E. ; Fastenau, Philip S. ; Sweet, Jennifer ; Lüders, Hans ; Miller, Jonathan P. / Resection of temporal neocortex during multiple hippocampal transections for mesial temporal lobe epilepsy does not affect seizure or memory outcome. In: Operative Neurosurgery. 2017 ; Vol. 13, No. 6. pp. 711-717.
@article{1f59b64a7e504bc6bb8bad2bbce99fa7,
title = "Resection of temporal neocortex during multiple hippocampal transections for mesial temporal lobe epilepsy does not affect seizure or memory outcome",
abstract = "BACKGROUND: Multiple hippocampal transection (MHT) is a surgical treatment for mesial temporal lobe epilepsy associated with improved postoperative neuropsychological outcomes compared with lobectomy. OBJECTIVE: To determine whether resection of the amygdala and anterior temporal neocortex during MHT affects postoperative seizure/memory outcome. METHODS: Seventeen patients with normal magnetic resonance imaging and stereoelectroencephalogram- proven drug-resistant dominant mesial temporal lobe epilepsy were treated with MHT. Nine patients underwent MHT alone (MHT-) and 8 patients underwent MHT plus removal of the amygdala and anterior 4.5 cm of temporal neocortex lateral to the fusiform gyrus (MHT+). Verbal and visual-spatial memory were assessed in all patients preoperatively and in 14 patients postoperatively using the Wechsler Memory Scale. Postoperative seizure control was assessed at 12 months for all patients. RESULTS: Overall, 11 of 17 patients (64.7{\%})were Engel class 1 at 1 year (6/9 MHT-, 5/8 MHT+, P = .38), and 10 of 14 patients (71.4{\%}) had no significant postoperative decline in either verbal or visual memory (6/8 MHT-, 4/6 MHT+, P = .42). Verbal memory declined in 2 of 8 MHT- and 1 of 6 MHT+ patients, and visual memory declined in 1 of 8 MHT- and 2 of 6 MHT+ patients. Two patients had improved visual memory postoperatively, both in the MHT+ group. CONCLUSION: MHT on the dominant side is associated with high rates of seizure freedom and favorable memory preservation outcomes regardless of the extent of neocortical resection. Preservation of the temporal neocortex and amygdala during MHT does not appear to decrease the risk of postoperative memory decline, nor does it alter seizure outcome.",
keywords = "Epilepsy, Memory, Multiple hippocampal transections",
author = "Fady Girgis and Greil, {Madeline E.} and Fastenau, {Philip S.} and Jennifer Sweet and Hans L{\"u}ders and Miller, {Jonathan P.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1093/ons/opx031",
language = "English (US)",
volume = "13",
pages = "711--717",
journal = "Operative Neurosurgery",
issn = "2332-4252",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Resection of temporal neocortex during multiple hippocampal transections for mesial temporal lobe epilepsy does not affect seizure or memory outcome

AU - Girgis, Fady

AU - Greil, Madeline E.

AU - Fastenau, Philip S.

AU - Sweet, Jennifer

AU - Lüders, Hans

AU - Miller, Jonathan P.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - BACKGROUND: Multiple hippocampal transection (MHT) is a surgical treatment for mesial temporal lobe epilepsy associated with improved postoperative neuropsychological outcomes compared with lobectomy. OBJECTIVE: To determine whether resection of the amygdala and anterior temporal neocortex during MHT affects postoperative seizure/memory outcome. METHODS: Seventeen patients with normal magnetic resonance imaging and stereoelectroencephalogram- proven drug-resistant dominant mesial temporal lobe epilepsy were treated with MHT. Nine patients underwent MHT alone (MHT-) and 8 patients underwent MHT plus removal of the amygdala and anterior 4.5 cm of temporal neocortex lateral to the fusiform gyrus (MHT+). Verbal and visual-spatial memory were assessed in all patients preoperatively and in 14 patients postoperatively using the Wechsler Memory Scale. Postoperative seizure control was assessed at 12 months for all patients. RESULTS: Overall, 11 of 17 patients (64.7%)were Engel class 1 at 1 year (6/9 MHT-, 5/8 MHT+, P = .38), and 10 of 14 patients (71.4%) had no significant postoperative decline in either verbal or visual memory (6/8 MHT-, 4/6 MHT+, P = .42). Verbal memory declined in 2 of 8 MHT- and 1 of 6 MHT+ patients, and visual memory declined in 1 of 8 MHT- and 2 of 6 MHT+ patients. Two patients had improved visual memory postoperatively, both in the MHT+ group. CONCLUSION: MHT on the dominant side is associated with high rates of seizure freedom and favorable memory preservation outcomes regardless of the extent of neocortical resection. Preservation of the temporal neocortex and amygdala during MHT does not appear to decrease the risk of postoperative memory decline, nor does it alter seizure outcome.

AB - BACKGROUND: Multiple hippocampal transection (MHT) is a surgical treatment for mesial temporal lobe epilepsy associated with improved postoperative neuropsychological outcomes compared with lobectomy. OBJECTIVE: To determine whether resection of the amygdala and anterior temporal neocortex during MHT affects postoperative seizure/memory outcome. METHODS: Seventeen patients with normal magnetic resonance imaging and stereoelectroencephalogram- proven drug-resistant dominant mesial temporal lobe epilepsy were treated with MHT. Nine patients underwent MHT alone (MHT-) and 8 patients underwent MHT plus removal of the amygdala and anterior 4.5 cm of temporal neocortex lateral to the fusiform gyrus (MHT+). Verbal and visual-spatial memory were assessed in all patients preoperatively and in 14 patients postoperatively using the Wechsler Memory Scale. Postoperative seizure control was assessed at 12 months for all patients. RESULTS: Overall, 11 of 17 patients (64.7%)were Engel class 1 at 1 year (6/9 MHT-, 5/8 MHT+, P = .38), and 10 of 14 patients (71.4%) had no significant postoperative decline in either verbal or visual memory (6/8 MHT-, 4/6 MHT+, P = .42). Verbal memory declined in 2 of 8 MHT- and 1 of 6 MHT+ patients, and visual memory declined in 1 of 8 MHT- and 2 of 6 MHT+ patients. Two patients had improved visual memory postoperatively, both in the MHT+ group. CONCLUSION: MHT on the dominant side is associated with high rates of seizure freedom and favorable memory preservation outcomes regardless of the extent of neocortical resection. Preservation of the temporal neocortex and amygdala during MHT does not appear to decrease the risk of postoperative memory decline, nor does it alter seizure outcome.

KW - Epilepsy

KW - Memory

KW - Multiple hippocampal transections

UR - http://www.scopus.com/inward/record.url?scp=85042253255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042253255&partnerID=8YFLogxK

U2 - 10.1093/ons/opx031

DO - 10.1093/ons/opx031

M3 - Article

C2 - 29186594

AN - SCOPUS:85042253255

VL - 13

SP - 711

EP - 717

JO - Operative Neurosurgery

JF - Operative Neurosurgery

SN - 2332-4252

IS - 6

ER -