Research resource: Identification of novel coregulators specific for thyroid hormone receptor-β2

Johnnie B. Hahm, Martin L. Privalsky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Thyroid hormone receptors (TRs) are expressed as a series of interrelated isoforms that perform distinct biological roles. The TRβ2 isoform is found predominantly in the hypothalamus, pituitary, retina, and cochlea and displays unique transcriptional properties relative to the other TR isoforms. To more fully understand the isoform-specific biological and molecular properties of TRβ2, we have identified a series of previously unrecognized proteins that selectively interact with TRβ2 compared with the more widely expressed TRβ1. Several of these proteins preferentially enhance the transcriptional activity of TRβ2 when coexpressed in cells and are likely to represent novel, isoform-specific coactivators. Additional proteins were also identified in our screen that bind equally to TRβ1 and TRβ2 and may function as isoform-independent auxiliary proteins for these and/or other nuclear receptors. We propose that a combination of isoform-specific recruitment and tissue-specific expression of these newly identified coregulator candidates serves to customize TR function for different biological purposes in different cell types.

Original languageEnglish (US)
Pages (from-to)840-859
Number of pages20
JournalMolecular Endocrinology
Volume27
Issue number5
DOIs
StatePublished - May 1 2013

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Thyroid Hormone Receptors
Protein Isoforms
Research
Proteins
Cochlea
Cytoplasmic and Nuclear Receptors
Hypothalamus
Retina

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

Research resource : Identification of novel coregulators specific for thyroid hormone receptor-β2. / Hahm, Johnnie B.; Privalsky, Martin L.

In: Molecular Endocrinology, Vol. 27, No. 5, 01.05.2013, p. 840-859.

Research output: Contribution to journalArticle

Hahm, Johnnie B. ; Privalsky, Martin L. / Research resource : Identification of novel coregulators specific for thyroid hormone receptor-β2. In: Molecular Endocrinology. 2013 ; Vol. 27, No. 5. pp. 840-859.
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