Reproductive outcomes in relation to malathion spraying in the San Francisco Bay area, 1981-1982

D. C. Thomas, D. B. Petitti, M. Goldhaber, S. H. Swan, E. B. Rappaport, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

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Abstract

We studied reproductive outcomes in a cohort of 7,450 pregnancies identified through three Kaiser-Permanente facilities in the San Francisco Bay Area, in relation to exposure to the pesticide malathion, applied aerially to control an infestation by the Mediterranean fruit fly. We included in the cohort all women over age 17 who were registered at these facilities and who were confirmed as pregnant during the spraying period. Residence histories throughout the pregnancy were obtained by mailed questionnaire or telephone interview from 933 women with adverse outcomes and a sample of 1,000 women with normal outcomes, and were converted to geographical coordinates. We linked the coordinates for malathion spraying corridors with the residence coordinates to create individual exposure indices for each week of pregnancy. The statistical analysis compared each of the adverse pregnancy outcome groups against an appropriate control group using logistic regression or survival time regression approaches. After adjustment for various confounders, no important association was found between malathion exposure and spontaneous abortion, intrauterine growth retardation, stillbirth, or most categories of congenital anomalies. Gastrointestinal anomalies were related to second trimester exposure (odds ratio = 2.6), based on 13 cases and not specific to any particular International Classification of Diseases code.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalEpidemiology
Volume3
Issue number1
StatePublished - 1992

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Malathion
San Francisco
Ceratitis capitata
Pregnancy
Reproductive History
Stillbirth
Fetal Growth Retardation
Second Pregnancy Trimester
International Classification of Diseases
Spontaneous Abortion
Pregnancy Outcome
Pesticides
Logistic Models
Odds Ratio
Interviews
Control Groups
Survival

ASJC Scopus subject areas

  • Epidemiology

Cite this

Thomas, D. C., Petitti, D. B., Goldhaber, M., Swan, S. H., Rappaport, E. B., & Hertz-Picciotto, I. (1992). Reproductive outcomes in relation to malathion spraying in the San Francisco Bay area, 1981-1982. Epidemiology, 3(1), 32-39.

Reproductive outcomes in relation to malathion spraying in the San Francisco Bay area, 1981-1982. / Thomas, D. C.; Petitti, D. B.; Goldhaber, M.; Swan, S. H.; Rappaport, E. B.; Hertz-Picciotto, Irva.

In: Epidemiology, Vol. 3, No. 1, 1992, p. 32-39.

Research output: Contribution to journalArticle

Thomas, DC, Petitti, DB, Goldhaber, M, Swan, SH, Rappaport, EB & Hertz-Picciotto, I 1992, 'Reproductive outcomes in relation to malathion spraying in the San Francisco Bay area, 1981-1982', Epidemiology, vol. 3, no. 1, pp. 32-39.
Thomas, D. C. ; Petitti, D. B. ; Goldhaber, M. ; Swan, S. H. ; Rappaport, E. B. ; Hertz-Picciotto, Irva. / Reproductive outcomes in relation to malathion spraying in the San Francisco Bay area, 1981-1982. In: Epidemiology. 1992 ; Vol. 3, No. 1. pp. 32-39.
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