Reproductive aging of females

Neural systems

R. D. Brinton, A. C. Gore, P. J. Schmidt, John Morrison

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Although reproductive senescence is defined by oocyte depletion, reproductive aging results from the complex interplay of age-dependent endocrine changes and the hypothalamic-pituitary-gonadal axis. In women, the transition from a reproductive life stage to postmenopausal life stage is a dynamic process that occurs in stages that have both discrete endocrine events and variable parameters. The contributions from basic neuroscience in cells and animal models and from clinical trials of hormone therapy during menopause have dramatically enhanced the current understanding of reproductive aging in the brain. Here, the state of research of reproductive aging in the hypothalamus, hippocampus, and prefrontal cortex as well as the current understanding of hormone therapy are described with regard to the brain, cognition, and mood function throughout the menopause transition. As the worldwide population ages and more than 1.2 billion women become 50 years old or older in 2030, understanding of the complexity of these hormone-brain circuits and translating those insights into healthy aging strategies will become ever more critical.

Original languageEnglish (US)
Title of host publicationHormones, Brain and Behavior Online
PublisherElsevier Inc.
Pages2199-2224
Number of pages26
ISBN (Print)9780080887838
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Hormones
Menopause
Brain
Neurosciences
Prefrontal Cortex
Cognition
Hypothalamus
Oocytes
Hippocampus
Animal Models
Clinical Trials
Therapeutics
Research
Population

Keywords

  • Aging
  • Alzheimer's disease
  • Estrogen/hormone therapy
  • Menopause
  • Perimenopause
  • Signaling cascades

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brinton, R. D., Gore, A. C., Schmidt, P. J., & Morrison, J. (2010). Reproductive aging of females: Neural systems. In Hormones, Brain and Behavior Online (pp. 2199-2224). Elsevier Inc.. https://doi.org/10.1016/B978-008088783-8.00068-1

Reproductive aging of females : Neural systems. / Brinton, R. D.; Gore, A. C.; Schmidt, P. J.; Morrison, John.

Hormones, Brain and Behavior Online. Elsevier Inc., 2010. p. 2199-2224.

Research output: Chapter in Book/Report/Conference proceedingChapter

Brinton, RD, Gore, AC, Schmidt, PJ & Morrison, J 2010, Reproductive aging of females: Neural systems. in Hormones, Brain and Behavior Online. Elsevier Inc., pp. 2199-2224. https://doi.org/10.1016/B978-008088783-8.00068-1
Brinton RD, Gore AC, Schmidt PJ, Morrison J. Reproductive aging of females: Neural systems. In Hormones, Brain and Behavior Online. Elsevier Inc. 2010. p. 2199-2224 https://doi.org/10.1016/B978-008088783-8.00068-1
Brinton, R. D. ; Gore, A. C. ; Schmidt, P. J. ; Morrison, John. / Reproductive aging of females : Neural systems. Hormones, Brain and Behavior Online. Elsevier Inc., 2010. pp. 2199-2224
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