Reports of oligodendrogliomas in three white-tailed deer (Odocoileus virginianus)

Nicole L. Gottdenker, Richard Gerhold, Andrew Cartoceti, Michael K Keel, James P. Goltz, Elizabeth Howerth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Central nervous system tumors are rarely reported in cervids. The current report describes gross and histopathologic oligodendrogliomas in 3 white-tailed deer (Odocoileus virginianus), and selected immunohistochemical properties of 2 deer. All deer were euthanized due to central nervous system signs. Grossly, masses were variably circumscribed, locally invasive in the brain, light grey, and soft, and ranged from 2 to 5 cm in diameter. Histologically, tumors were characteristic for oligodendroglioma. The tumors were composed primarily of oval to round cells with round normochromatic to hyperchromatic nuclei, a pale granular cytoplasm, and well-delineated cytoplasmic membrane, and variable amounts of mucinous material, hemorrhage, and dystrophic mineralization. Immunohistochemistry, performed on masses from 2 deer, had positive cytoplasmic staining for S100 and variable staining on glial fibrillary acidic protein (1 deer negative and the other with rare positivity in astrocytes within the mass). This manuscript includes a discussion on the significance of these findings relative to central nervous system tumors of cervids and oligodendrogliomas from other species.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume24
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Oligodendroglioma
Deer
Odocoileus virginianus
deer
central nervous system
neoplasms
Central Nervous System Neoplasms
astrocytes
Staining and Labeling
neuroglia
Glial Fibrillary Acidic Protein
hemorrhage
immunohistochemistry
cell membranes
mineralization
cytoplasm
Astrocytes
Neoplasms
brain
Cytoplasm

Keywords

  • Central nervous system
  • neoplasia
  • Odocoileus virginianus
  • oligodendroglioma
  • white-tailed deer
  • wildlife

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Reports of oligodendrogliomas in three white-tailed deer (Odocoileus virginianus). / Gottdenker, Nicole L.; Gerhold, Richard; Cartoceti, Andrew; Keel, Michael K; Goltz, James P.; Howerth, Elizabeth.

In: Journal of Veterinary Diagnostic Investigation, Vol. 24, No. 1, 01.2012, p. 202-206.

Research output: Contribution to journalArticle

Gottdenker, Nicole L. ; Gerhold, Richard ; Cartoceti, Andrew ; Keel, Michael K ; Goltz, James P. ; Howerth, Elizabeth. / Reports of oligodendrogliomas in three white-tailed deer (Odocoileus virginianus). In: Journal of Veterinary Diagnostic Investigation. 2012 ; Vol. 24, No. 1. pp. 202-206.
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