Abstract
Central nervous system tumors are rarely reported in cervids. The current report describes gross and histopathologic oligodendrogliomas in 3 white-tailed deer (Odocoileus virginianus), and selected immunohistochemical properties of 2 deer. All deer were euthanized due to central nervous system signs. Grossly, masses were variably circumscribed, locally invasive in the brain, light grey, and soft, and ranged from 2 to 5 cm in diameter. Histologically, tumors were characteristic for oligodendroglioma. The tumors were composed primarily of oval to round cells with round normochromatic to hyperchromatic nuclei, a pale granular cytoplasm, and well-delineated cytoplasmic membrane, and variable amounts of mucinous material, hemorrhage, and dystrophic mineralization. Immunohistochemistry, performed on masses from 2 deer, had positive cytoplasmic staining for S100 and variable staining on glial fibrillary acidic protein (1 deer negative and the other with rare positivity in astrocytes within the mass). This manuscript includes a discussion on the significance of these findings relative to central nervous system tumors of cervids and oligodendrogliomas from other species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 202-206 |
| Number of pages | 5 |
| Journal | Journal of Veterinary Diagnostic Investigation |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
| Externally published | Yes |
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Keywords
- Central nervous system
- neoplasia
- Odocoileus virginianus
- oligodendroglioma
- white-tailed deer
- wildlife
ASJC Scopus subject areas
- veterinary(all)
Cite this
Reports of oligodendrogliomas in three white-tailed deer (Odocoileus virginianus). / Gottdenker, Nicole L.; Gerhold, Richard; Cartoceti, Andrew; Keel, Michael K; Goltz, James P.; Howerth, Elizabeth.
In: Journal of Veterinary Diagnostic Investigation, Vol. 24, No. 1, 01.2012, p. 202-206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reports of oligodendrogliomas in three white-tailed deer (Odocoileus virginianus)
AU - Gottdenker, Nicole L.
AU - Gerhold, Richard
AU - Cartoceti, Andrew
AU - Keel, Michael K
AU - Goltz, James P.
AU - Howerth, Elizabeth
PY - 2012/1
Y1 - 2012/1
N2 - Central nervous system tumors are rarely reported in cervids. The current report describes gross and histopathologic oligodendrogliomas in 3 white-tailed deer (Odocoileus virginianus), and selected immunohistochemical properties of 2 deer. All deer were euthanized due to central nervous system signs. Grossly, masses were variably circumscribed, locally invasive in the brain, light grey, and soft, and ranged from 2 to 5 cm in diameter. Histologically, tumors were characteristic for oligodendroglioma. The tumors were composed primarily of oval to round cells with round normochromatic to hyperchromatic nuclei, a pale granular cytoplasm, and well-delineated cytoplasmic membrane, and variable amounts of mucinous material, hemorrhage, and dystrophic mineralization. Immunohistochemistry, performed on masses from 2 deer, had positive cytoplasmic staining for S100 and variable staining on glial fibrillary acidic protein (1 deer negative and the other with rare positivity in astrocytes within the mass). This manuscript includes a discussion on the significance of these findings relative to central nervous system tumors of cervids and oligodendrogliomas from other species.
AB - Central nervous system tumors are rarely reported in cervids. The current report describes gross and histopathologic oligodendrogliomas in 3 white-tailed deer (Odocoileus virginianus), and selected immunohistochemical properties of 2 deer. All deer were euthanized due to central nervous system signs. Grossly, masses were variably circumscribed, locally invasive in the brain, light grey, and soft, and ranged from 2 to 5 cm in diameter. Histologically, tumors were characteristic for oligodendroglioma. The tumors were composed primarily of oval to round cells with round normochromatic to hyperchromatic nuclei, a pale granular cytoplasm, and well-delineated cytoplasmic membrane, and variable amounts of mucinous material, hemorrhage, and dystrophic mineralization. Immunohistochemistry, performed on masses from 2 deer, had positive cytoplasmic staining for S100 and variable staining on glial fibrillary acidic protein (1 deer negative and the other with rare positivity in astrocytes within the mass). This manuscript includes a discussion on the significance of these findings relative to central nervous system tumors of cervids and oligodendrogliomas from other species.
KW - Central nervous system
KW - neoplasia
KW - Odocoileus virginianus
KW - oligodendroglioma
KW - white-tailed deer
KW - wildlife
UR - http://www.scopus.com/inward/record.url?scp=84857292128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857292128&partnerID=8YFLogxK
U2 - 10.1177/1040638711425570
DO - 10.1177/1040638711425570
M3 - Article
C2 - 22362955
AN - SCOPUS:84857292128
VL - 24
SP - 202
EP - 206
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
IS - 1
ER -