Replication and cytopathic effects of ovine lentivirus strains in alveolar macrophages correlate with in vivo pathogenicity

Michael Dale Lairmore, G. Y. Akita, H. I. Russell, J. C. DeMartini

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Ruminant lentiviruses share genomic sequences and biologic properties with human immunodeficiency viruses. Four ovine lentivirus strains were assessed for cytopathic effects and virus replication. Lentivirus isolate H/24 produced high virus titers and lysis of synovial cells but replicated slowly and caused no fusion of alveolar macrophages. Lentivirus isolates 84/28 and 85/14 produced low virus titers, less syncytia, and limited or no cell lysis in synovial cells and macrophages. In contrast, ovine lentivirus isolate 84/34 produced early peak virus titers and caused rapid fusion and lysis of both macrophages and synovial cells. Ovine lentivirus isolates which were cytopathic for macrophages induced lymphoproliferative disease when inoculated into lambs.

Original languageEnglish (US)
Pages (from-to)4038-4042
Number of pages5
JournalJournal of Virology
Volume61
Issue number12
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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