Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP

Jill L Silverman, Seda S. Tolu, Charlotte L. Barkan, Jacqueline Crawley

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR Ttf/J (BTBR) is an inbred mouse strain that shows robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of autism, including well-replicated deficits in reciprocal social interactions and social approach, unusual patterns of ultrasonic vocalization, and high levels of repetitive self-grooming. These phenotypes offer straightforward behavioral assays for translational investigations of pharmacological compounds. Two suggested treatments for autism were evaluated in the BTBR mouse model. Methyl-6-phenylethynyl-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, blocks aberrant phenotypes in the Fmr1 mouse model of Fragile X, a comorbid neurodevelopmental disorder with autistic features. Risperidone has been approved by the United States Food and Drug Administration for the treatment of irritability, tantrums, and self-injurious behavior in autistic individuals. We evaluated the actions of MPEP and risperidone on two BTBR phenotypes, low sociability and high repetitive self-grooming. Open field activity served as an independent control for non-social exploratory activity and motor functions. C57BL/6J (B6), an inbred strain with high sociability and low self-grooming, served as the strain control. MPEP significantly reduced repetitive self-grooming in BTBR, at doses that had no sedating effects on open field activity. Risperidone reduced repetitive self-grooming in BTBR, but only at doses that induced sedation in both strains. No overall improvements in sociability were detected in BTBR after treatment with either MPEP or risperidone. Our findings suggest that antagonists of mGluR5 receptors may have selective therapeutic efficacy in treating repetitive behaviors in autism.

Original languageEnglish (US)
Pages (from-to)976-989
Number of pages14
JournalNeuropsychopharmacology
Volume35
Issue number4
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Grooming
Autistic Disorder
Risperidone
Phenotype
Interpersonal Relations
Self-Injurious Behavior
Inbred Strains Mice
Metabotropic Glutamate Receptors
United States Food and Drug Administration
Ultrasonics
Motor Activity
Communication
pyridine
Pharmacology

Keywords

  • Autism
  • BTBR
  • MGluR5
  • Mouse models
  • Repetitive behavior
  • Social behavior

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. / Silverman, Jill L; Tolu, Seda S.; Barkan, Charlotte L.; Crawley, Jacqueline.

In: Neuropsychopharmacology, Vol. 35, No. 4, 03.2010, p. 976-989.

Research output: Contribution to journalArticle

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