Repeated administration of desmethylimipramine blocks the reserpine-induced increase in tyrosine hydroxylase mRNA in locus coeruleus neurons of the rat

M. Schultzberg, M. C. Austin, Jacqueline Crawley, S. M. Paul

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The levels of tyrosine hydroxylase and galanin mRNA were measured by in situ hybridization histochemistry in the rat locus coeruleus after repeated (21 days) administration of desmethylimipramine (10 mg/kg/day), of reserpine (0.25 mg/kg/day), of coadministered desmethylimipramine and reserpine, or of vehicle. Reserpine administration resulted in increased levels of both tyrosine hydroxylase and galanin mRNAs in locus coeruleus neurons as compared to vehicle-treated controls. Administration of desmethylimipramine alone failed to alter either the tyrosine hydroxylase or galanin mRNA. However, coadministration of desmethylimipramine with reserpine blocked the elevation in tyrosine hydroxylase mRNA induced by reserpine alone.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalMolecular Brain Research
Volume10
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Coexistence
  • Galanin
  • Gene regulation
  • Noradrenaline
  • Tricyclic antidepressant

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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